ArticleAAPS PharmSciTech2026
High-Contrast X-Ray Computed Tomography for Quantifying Amorphous Content in Melt-Quenched Acetaminophen.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
X-ray computed tomography (XRCT) allows for non-destructive three-dimensional observation and volumetric quantification of samples. It also allows for structural changes monitoring, such as the amorphous-to-crystalline transition in pharmaceuticals, over time. Despite past applications of XRCT to characterize amorphous pharmaceuticals, its quantitative validity has not been systematically verified against established thermal methods. Here, we evaluated laboratory XRCT for monitoring the crystallization behavior of amorphous acetaminophen and validated its accuracy via differential scanning calorimetry (DSC). In XRCT, amorphous content was determined from voxel-based phase segmentation, while DSC estimates were obtained from the specific heat change at the glass transition temperature. Time-dependent crystallization at 30°C was quantified using XRCT followed immediately by DSC, showing strong correlation (R
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