Evidence map›Paper›PMID 41709049›Full record

ArticleCardiovascular engineering and technology2026

Hemodynamic Shear Stress Patterns in Abdominal Aortic Aneurysms and Healthy Aortas: A CFD Study.

Spyridon C Katsoudas, Panagiotis D Linardopoulos, Anastasios A Raptis, Konstantinos G Moulakakis, John D Kakisis, Konstantinos T Spanos, Miltiadis I Matsagkas, Athanasios D Giannoukas, Christos G Manopoulos, Efstratios E Tzirtzilakis and 1 more

Abstract readComparative Study
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Article in Cardiovascular engineering and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Spyridon C KatsoudasDepartment of Mathematics, University of Ioannina, Ioannina, 45110, Greece.
Panagiotis D LinardopoulosDepartment of Mathematics, University of Ioannina, Ioannina, 45110, Greece.
Anastasios A RaptisLaboratory of Biofluid Mechanics & Biomedical Technology, School of Mechanical Engineering, National Technical University of Athens, Athens, Zografou, 15772, Greece.
Konstantinos G MoulakakisDepartment of Vascular Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, 10679, Greece.
John D KakisisDepartment of Vascular Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, 10679, Greece.
Konstantinos T SpanosDepartment of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, 41334, Greece.
Miltiadis I MatsagkasDepartment of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, 41334, Greece.
Athanasios D GiannoukasDepartment of Vascular Surgery, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, 41334, Greece.
Christos G ManopoulosLaboratory of Biofluid Mechanics & Biomedical Technology, School of Mechanical Engineering, National Technical University of Athens, Athens, Zografou, 15772, Greece.
Efstratios E TzirtzilakisDepartment of Civil Engineering, University of the Peloponnese, Patras, 26334, Greece.
Michalis A XenosDepartment of Mathematics, University of Ioannina, Ioannina, 45110, Greece. mxenos@uoi.gr.ORCID 0000-0001-8441-1306

Funding

European Union-NextGeneration TAEDR-0535983
6 · The paper itself

Abstract

purposeAbdominal aortic aneurysms (AAAs) remain a major cause of mortality, with rupture risk still primarily assessed by maximum diameter. Specialized hemodynamic indices from Computational Fluid Dynamics (CFD) may provide predictive insight into AAA progression.

methodsWe performed a comparative CFD study of 10 healthy-control infrarenal aortas and 15 AAAs, utilizing the open source software SimVascular. Blood was modeled as a Newtonian fluid and pulsatile inlet conditions were applied, extracted from multiscale modeling. Three-element Windkessel (RCR) models were imposed at the iliac outlets to capture physiologic flow distribution. Time Averaged Wall Shear Stress (TAWSS), Oscillatory Shear Index (OSI) and Relative Residence Time (RRT) surface area coverage exposed to pathological regimes were quantified and compared between healthy and pathological models. Statistical analysis in two separate regions, the proximal neck/aneurysm sac and the iliacs, was conducted.

resultsPathological-AAA models exhibited significantly bigger surface coverage of low TAWSS and high RRT compared to the healthy aortas in both studied areas. Although the coverage area of OSI was larger in AAAs, it didn't reach statistical significance at the infrarenal part, but only at the iliac region.

conclusionThe surface area exposed to lower shear and prolonged residence time provides strong evidence of AAA pathology in contrast with OSI, which offers limited information and cannot be a standalone index of pathology. These findings suggest that integrating TAWSS and RRT into clinical assessment may improve the prediction of aneurysm progression and rupture risk beyond diameter-based criteria.

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalHemodynamicsModels, CardiovascularAgedBlood Flow VelocityCase-Control StudiesComputer SimulationDisease ProgressionFemaleHumansHydrodynamicsMaleMiddle AgedPulsatile FlowRegional Blood FlowAbdominal aortic aneurysm (AAA)Computational fluid dynamics (CFD)Oscillatory shear index (OSI)RCR boundary conditionsRelative Residence Time (RRT)Time Averaged Wall shear stress (TAWSS)

Identifiers

PMID41709049

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