ArticleNature microbiology2026
Longitudinal plasma metabolomics reveals a role for taurine in asymptomatic malaria and seasonal persistence.
Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- How taurine keeps asymptomatic malaria infections in check.Nature microbiology · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
In malaria-endemic regions, asymptomatic Plasmodium falciparum infections during periods of low transmission alternate with symptomatic infections during periods of high transmission. The mechanisms underlying P. falciparum persistence without causing symptoms during low-transmission periods remain unclear. Here we analysed the plasma metabolome (n = 199) of individuals in the Gambia, West Africa, during the high and low malaria transmission periods. We observed significant metabolome changes associated with seasonality and to a lesser extent with malaria pathogenicity. We show that plasma levels of taurine, an amino sulfonic acid, increase longitudinally during periods of low transmission. Although taurine showed no effect on the development of cultured parasites in vitro, it strongly inhibited and prevented malaria-infected red blood cell (iRBC) adhesion via PfEMP1 to the common adhesion receptor CD36 and the endothelial protein C receptor, which is linked to cerebral malaria. We reveal a role for taurine in reducing cytoadhesion, which could inform strategies to reduce symptomatic malaria in sub-Saharan Africa.
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