Evidence map›Paper›PMID 41708869›Full record

ArticleNature2026

Ancestry and somatic profile indicate acral melanoma origin and prognosis.

Patricia Basurto-Lozada, Martha Estefania Vázquez-Cruz, Christian Molina-Aguilar, Amanda Jiang, Dekker C Deacon, Dennis Cerrato-Izaguirre, Irving Simonin-Wilmer, Fernanda G Arriaga-González, Kenya L Contreras-Ramírez, Emiliano Ferro-Rodríguez and 33 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors.

Patricia Basurto-LozadaLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.ORCID 0009-0005-8376-7753
Martha Estefania Vázquez-CruzLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.
Christian Molina-AguilarLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.ORCID 0000-0002-9670-252X
Amanda JiangHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.ORCID 0000-0002-0327-6980
Dekker C DeaconHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Dennis Cerrato-IzaguirreSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.ORCID 0000-0002-6556-1998
Irving Simonin-WilmerLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.
Fernanda G Arriaga-GonzálezLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.ORCID 0009-0009-4589-8604
Kenya L Contreras-RamírezLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.ORCID 0000-0001-6169-0568
Emiliano Ferro-RodríguezLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.ORCID 0009-0003-3056-5061
Jamie BillingtonWellcome Sanger Institute, Hinxton, UK.
Eric T DawsonEarthFrame Corporation, Bryan, TX, USA.
J Rene C Wong-RamirezLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.ORCID 0009-0002-3850-272X
Johana Itzel Ramos-GalgueraLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.ORCID 0009-0000-7563-4209
Alethia Álvarez-CanoDepartamento de Cirugía Oncológica, Hospital NOVA, Universidad de Monterrey UDEM, Monterrey, Mexico.ORCID 0000-0002-2485-3409
Dorian Y García-OrtegaSurgical Oncology, Skin, Soft Tissue and Bone Tumors Department, National Cancer Institute, Mexico City, Mexico.ORCID 0000-0002-1302-2896
O Isaac García-SalinasLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.
Alfredo Hidalgo-MirandaLaboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.ORCID 0000-0003-2315-3977
Mireya Cisneros-VillanuevaLaboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.ORCID 0000-0002-5662-0247
Peter A JohanssonQIMR Berghofer, Brisbane, Queensland, Australia.ORCID 0000-0001-7015-5452
Héctor Martínez-SaidSurgical Oncology, Skin, Soft Tissue and Bone Tumors Department, National Cancer Institute, Mexico City, Mexico.ORCID 0000-0002-9881-4592
Pilar Gallego-GarcíaDigital Genomics Group, Cancer Genomics Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.ORCID 0000-0001-8531-9851
Mark J ArendsEdinburgh Pathology, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-6826-8770
Ingrid FerreiraWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-4321-5250
Mark TullettDepartment of Histopathology, University Hospitals Sussex, St Richard Hospital, Chichester, UK.
Rebeca Olvera-LeónLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.
Louise van der WeydenWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-0645-1879
Martín Del Castillo Velasco-HerreraWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-5956-0211
Rodrigo Roldán-MarínDermato-Oncology Clinic, Research Division, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.ORCID 0000-0002-6832-5915
Helena Vidaurri de la CruzPediatric Dermatology Service, Hospital General de México Dr. Eduardo Liceaga, Ministry of Health, Mexico City, Mexico.ORCID 0000-0002-7617-1610
Luis Alberto Tavares-de-la-PazSurgical Oncology, Bajio Regional High Specialty Hospital, Leon, Mexico.
Diego Hinojosa-UgarteDivision of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.ORCID 0000-0003-2896-0700
Rachel L BeloteDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-3001-0002
D Timothy BishopLeeds Institute of Medical Research, University of Leeds, Leeds, UK.ORCID 0000-0002-8752-8785
Marcos Díaz-GayDigital Genomics Group, Cancer Genomics Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.ORCID 0000-0003-0658-0467
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3596-4515
Yesennia Sánchez-PérezSubdirección de Investigación Básica, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.
Gino K InDivision of Oncology, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Richard M WhiteNuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.ORCID 0000-0001-9099-9169
Patrícia A PossikWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-2899-0969
Robert L Judson-TorresHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.ORCID 0000-0002-6559-0553
David J AdamsWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-9490-0306
Carla Daniela Robles-EspinozaLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico. drobles@liigh.unam.mx.ORCID 0000-0003-3277-7466

Funding

Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Karin · 2024 to 2026
$9.2M
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4M
Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1M
Comprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2M
Nevus associated microRNAs as mediators of BRAF-induced growth arrest and biomarkers of melanoma progressionR01CA229896 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JUDSON-TORRES, ROBERT LAIRD · 2021 to 2025
$1.8M
Understanding the origins of the mutational landscape in cancerR01ES036931 · NIEHS · UNIV OF ARKANSAS FOR MED SCIS · PI Ludmil B Alexandrov, Gunnar Boysen · 2025 to 2026
$1.5M
Exploring the Impact of Base Deaminase Deregulation on Precancer EvolutionR01CA296974 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Catriona Helen Macleod Jamieson · 2025 to 2026
$890k
NCI NIH HHS P01 CA281819NCI NIH HHS R01 CA229896NCI NIH HHS R01 CA269919NCI NIH HHS R01 CA296974NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547NIEHS NIH HHS R01 ES036931
6 · The paper itself

Abstract

Acral melanoma, which is not ultraviolet-associated, is the type of melanoma reported most commonly in several non-European-descent populations

Indexed as

MelanomaSkin NeoplasmsAdultAgedBlack PeopleFemaleGene Expression ProfilingGTP PhosphohydrolasesHispanic or LatinoHumansMaleMelanocytesMembrane ProteinsMexicoMiddle AgedMutationBRAF protein, humanGTP PhosphohydrolasesMembrane ProteinsNeurofibromin 1NF1 protein, humanNRAS protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID41708869
PMCPMC12960246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.