Evidence map›Paper›PMID 41708858›Full record

ArticleNature2026

Integrase anchors viral RNA to the HIV-1 capsid interior.

Matthew R Singer, Zhen Li, Juan S Rey, Joshua Hope, Florian Chenavier, Nicola J Cook, Emma Punch, Jamie Smith, Zhiyu Zhou, Sarah Maslen and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Mapping the vRNA Interaction with HIV-1 Integrase.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Matthew R SingerChromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.
Zhen LiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Juan S ReyDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA.ORCID http://orcid.org/0000-0003-2274-3748
Joshua HopeDivision of Structural Biology, Nuffield Department of Medicine, The University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2742-5538
Florian ChenavierChromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-9486-3944
Nicola J CookChromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-2738-7976
Emma PunchChromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.
Jamie SmithChromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.
Zhiyu ZhouChromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0009-0003-1329-5311
Sarah MaslenProteomics Science Technology Platform, The Francis Crick Institute, London, UK.
Laura MasinoStructural Biology Technology Platform, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-5326-7003
Andrea NansStructural Biology Technology Platform, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-3791-2447
Mark SkehelProteomics Science Technology Platform, The Francis Crick Institute, London, UK.
Ian A TaylorMacromolecular Structure Laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-6763-3852
Giulia ZanettiMembrane Architecture Laboratory, The Francis Crick Institute, London, UK.
Peijun ZhangDivision of Structural Biology, Nuffield Department of Medicine, The University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1803-691X
Juan R PerillaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA. JPerilla@udel.edu.ORCID http://orcid.org/0000-0003-1171-6816
Alan N EngelmanDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Alan_Engelman@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-9709-2591
Peter CherepanovChromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, UK. Peter.Cherepanov@crick.ac.uk.ORCID http://orcid.org/0000-0002-0634-538X

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peijun Zhang · 2022 to 2026
$30.6M
Determining the molecular mechanisms of HIV-1 maturationR01AI178846 · NIAID · UNIVERSITY OF DELAWARE · PI Juan Roberto Perilla Jimenez · 2023 to 2026
$2.3M
Correlative cryoET of the HIV-1 integration targeting in native T-lymphocytesR21AI184080 · NIAID · UNIVERSITY OF OXFORD · PI ZHANG, PEIJUN · 2024 to 2025
$285k
NIAID NIH HHS R01 AI178846NIAID NIH HHS R21 AI184080NIAID NIH HHS U54 AI170791Wellcome Discovery AwardWellcome Trust CC2029Wellcome Trust CC2058
6 · The paper itself

Abstract

HIV-1 integrase (IN) promotes encapsulation of viral genomic RNA into mature viral cores, and this function is a target for ongoing antiretroviral drug development efforts

Indexed as

CapsidHIV-1HIV IntegraseRNA, ViralAnimalsCapsid ProteinsCryoelectron MicroscopyHumansModels, MolecularProtein MultimerizationVirionCapsid ProteinsHIV Integrasep31 integrase protein, Human immunodeficiency virus 1RNA, Viral

Identifiers

PMID41708858
PMCPMC13102720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.