Evidence map›Paper›PMID 41708852›Full record

ArticleNature2026

Mucosal vaccination clears Clostridioides difficile colonization.

Audrey K Thomas, F Christopher Peritore-Galve, Alyssa G Ehni, Bruno B C Lança, Jonathan Coggin, Eric J Brady, Sandra M Yoder, Rebecca Shrem, Rubén Cano Rodríguez, Heather K Kroh and 7 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. A single amino acid substitution determines susceptibility ofFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Audrey K ThomasDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-3473-5289
F Christopher Peritore-GalveDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-0920-2285
Alyssa G EhniDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0009-0006-9164-2923
Bruno B C LançaDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jonathan CogginDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0009-0001-5890-1894
Eric J BradyVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-2717-5532
Sandra M YoderVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Rebecca ShremVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Rubén Cano RodríguezVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Heather K KrohDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Katherine N Gibson-CorleyDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-1846-1580
M Kay WashingtonDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Danyvid Olivares-VillagómezDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
C Buddy CreechVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Maribeth R NicholsonVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.
Benjamin W SpillerVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5397-1028
D Borden LacyDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. borden.lacy@vanderbilt.edu.ORCID http://orcid.org/0000-0003-2273-8121

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Antibody and Antigen Discovery for Clostridioides difficile VaccinesU19AI174999 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Maribeth Ruth Nicholson · 2023 to 2026
$7.9M
Structural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2M
BLRD VA I01 BX002943NIAID NIH HHS R37 AI095755NIAID NIH HHS U19 AI174999NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

Clostridioides difficile infection (CDI) is the leading cause of healthcare- and antibiotic-associated infection and has a 30% recurrence rate

Indexed as

Bacterial VaccinesClostridioides difficileClostridium InfectionsImmunity, MucosalVaccinationAnimalsAntigens, BacterialColonFecesFemaleImmunoglobulin GImmunologic MemoryMaleMemory T CellsMiceMice, Inbred C57BLAntigens, BacterialBacterial VaccinesImmunoglobulin G

Identifiers

PMID41708852
PMCPMC13128438

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.