Evidence map›Paper›PMID 41708744›Full record

Trial reportScientific reports2026

Mechanical power guided lung protective ventilation in acute respiratory failure using the VentCoach approach.

C Zheng, S W Abdulla, P R Bauer, P R M Rocco, J J Marini, R A Oeckler, G A Cortes-Puentes

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07294768 (Mechanical Power-Guided Lung Protective Ventilation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07294768 nacompletednot on this map

Mechanical Power-Guided Lung Protective Ventilation (VentCoach) in Acute Hypoxemic and/or Hypercapnic Respiratory Failure: A Feasibility, Double Arm, Single-blinded Study

TypeinterventionalSponsorMayo ClinicRan2023 to 2024Enrolled18ConditionsMechanical VentilationArmsVentCoach, Standard of Care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C ZhengDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
S W AbdullaDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
P R BauerDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
P R M RoccoLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373 - Cidade Universitária, Rio de Janeiro, RJ, 21941-170, Brazil.
J J MariniPulmonary and Critical Care Medicine, Regions Hospital, University of Minnesota, MS11203B 640 Jackson St., Minneapolis-St.Paul, St.Paul, MN, 55101, USA.
R A OecklerDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
G A Cortes-PuentesDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. CortesPuentes.Gustavo@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical power (MP) is increasingly recognized as a unifying variable that encapsulates ventilator-derived factors contributing to ventilator-induced lung injury. However, its clinical application remains limited by several challenges, including the lack of accessible real-time MP monitoring. This study aims to demonstrate the feasibility and safety of an electronic health record-integrated, MP-guided, and respiratory therapist (RT)-driven lung-protective ventilation (LPV) protocol (VentCoach). Single-center, single-blinded, randomized controlled feasibility trial utilizing block randomization to assign participants to either the standard care or VentCoach arm. Adult patients with acute hypoxemic and/or hypercapnic respiratory failure requiring intubation, admitted to medical or mixed medical-surgical ICUs at a tertiary care center in Rochester, Minnesota, were included in the study. The standard care arm received RT-driven lung-protective ventilation (LPV). The VentCoach arm received MP-guided adjustments to maintain mechanical power < 12 J/min while ensuring adequate gas exchange. Seventeen patients (n = 9 standard care, n = 8 VentCoach) were enrolled, demonstrating the feasibility of VentCoach without adverse events or workflow disruptions. No significant differences were observed in mortality, extubation time, dyssynchrony, or the use of sedation, analgesia, neuromuscular blockade, or vasoactive agents. The VentCoach group showed trends toward lower sedation requirements (− 25.9 mg/hour vs. +18.1 mg/hour, p = 0.09) and greater reduction in mechanical power over 24 h (− 2.0 J/min vs. + 0.6 J/min, p = 0.40), although these differences were not statistically significant. This feasibility study demonstrated practical implementation of the VentCoach protocol in a critical care setting, with no protocol-related adverse events or workflow disruptions in this limited cohort. While non-inferiority to standard lung-protective ventilation was observed, relationships between MP thresholds and clinical outcomes remain uncertain; directional signals support further study. Larger trials are needed to evaluate safety, MP reduction, and patient-centered outcomes (ClinicalTrials.gov Identifier: NCT07294768, Registration Date and Last Public Release: 12/08/2025).

Indexed as

Respiration, ArtificialRespiratory InsufficiencyVentilator-Induced Lung InjuryAgedFeasibility StudiesFemaleHumansMaleMiddle AgedSingle-Blind MethodAcute hypoxemic respiratory failureAcute respiratory distress syndrome (ARDS)Hypercapnic respiratory failureLung protective ventilationMechanical powerMechanical ventilationPositive end-expiratory pressure (PEEP)Respiratory therapyVentilator-induced lung injury (VILI)

Identifiers

PMID41708744
PMCPMC13013959

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.