ArticleScientific reports2026
Metabolomic profiling and biological evaluation demonstrate the antioxidant, PPAR-γ, TAAR1, and FABP4 modulatory potential of Strelitzia species.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strelitzia species, commonly known as the bird of paradise, are herbaceous perennial plants used as ornamentals owing to the beauty of their colored flowers. Due to lack of sufficient data on their chemical and pharmacological properties, the current study aimed to investigate the chemical profiles of two Egyptian Strelitzia species namely S. reginae Banks and S. nicolai Regel & Körn using multiplex of GC-MS and ESI-MS/MS metabolomics. Major components in the hexane extract of S. reginae Banks flowers were heneicosane, linoleic acid, and 17-octadecynoic acid whereas for S. nicolai Regel & Körn they were cumene, pseudocumene, hexahydrocumene, and propenyl cyclohexane. The hydrodistilled oil of S. reginae Banks flowers was enriched in caprylyl acetate, cembrene, caryophyllene, thunbergol, and verticilla-4(20),7,11-triene while for S. nicolai Regel & Körn they were heptacosane and 7-hexyleicosane. LC-MS/MS analysis of the methanol extracts of the leaves and flowers of both species revealed intra-and interspecies variations with general domination of phenolic acids, flavonoids, fatty acids, and phenolic derivatives. DPPH and FRAP analysis showed promising antioxidant activity for S. reginae Banks leaves. The hexane extract of S. reginae Banks showed agonistic activity to peroxisome proliferator activated receptor gamma (PPAR-γ) with EC50 value of 1.203 ± 0.045 µg/ml compared to rosiglitazone (EC50 = 0.292 ± 0.011 µg/ml), hinting at promising antidiabetic effect. Quantitative measurement of TAAR1 (trace amine associated receptor 1) levels in NCI-H810 cells treated with the hexane extract of S. reginae Banks flowers revealed remarkable decrease in its levels to 0.743 ± 0.025 ng/ml compared to untreated cells, hence showing premise for the treatment of depression and Parkinson disorders. The hexane extract of S. reginae Banks flowers moderately inhibited FABP4 (fatty acid binding protein 4) with IC50 value at 1.051 ± 0.028 µg/ml so it might be valuable for the management of hyperlipidemia and atherosclerosis. Our results were further supported by molecular docking studies to show the binding mechanisms of the natural ligands on their target proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.