Evidence map›Paper›PMID 41708636›Full record

ArticleNature communications2026

TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques.

Blanca Tardajos Ayllon, Mannekomba Diagbouga, Ankita Das, Siyu Tian, Andreas Edsfeldt, Joanna Kalucka, Jovana Serbanovic-Canic, Emily Chambers, Jiangming Sun, Chrysostomi Gialeli and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Blanca Tardajos Ayllon *Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-6466-8366
Mannekomba Diagbouga *Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-2641-5445
Ankita DasCentre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Siyu TianCentre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Andreas EdsfeldtCardiovascular Research Translational Studies, Clinical Sciences Malmö, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0002-2691-9192
Joanna KaluckaDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, 8000, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-4887-7672
Jovana Serbanovic-CanicSchool of Medicine and Population Health, INSIGNEO Institute, University of Sheffield, Sheffield, UK.
Emily ChambersSchool of Medicine and Population Health, INSIGNEO Institute, University of Sheffield, Sheffield, UK.
Jiangming SunCardiovascular Research Translational Studies, Clinical Sciences Malmö, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-6814-1297
Chrysostomi GialeliCardiovascular Research Translational Studies, Clinical Sciences Malmö, Lund University, Lund, Sweden.
Mark DunningSchool of Medicine and Population Health, INSIGNEO Institute, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0002-8853-9435
Sheila E FrancisSchool of Medicine and Population Health, INSIGNEO Institute, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0001-6552-0339
Xiuying LiDepartment of Pharmacy, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.
Akiko MammotoDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Michael SimonsYale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0348-7734
Helle F JørgensenSection of Cardiorespiratory Medicine, Department of Medicine, University of Cambridge, Victor Phillip Dahdaleh Heart and Lung Research Institute, Papworth Road, Cambridge, CB2 0BB, UK.ORCID http://orcid.org/0000-0002-7909-2977
Isabel GoncalvesCardiovascular Research Translational Studies, Clinical Sciences Malmö, Lund University, Lund, Sweden.
Suowen XuDepartment of Endocrinology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.ORCID http://orcid.org/0000-0002-5488-5217
Paul C EvansCentre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. paul.evans@qmul.ac.uk.ORCID http://orcid.org/0000-0001-7975-681X

Funding

British Heart Foundation (BHF) RG/19/10/34506
6 · The paper itself

Abstract

Rupture of unstable atherosclerotic plaques is a major cause of mortality. Endothelial-to-mesenchymal transition associates with advanced atherosclerotic plaques and contributes to plaque progression. We examined the role of Twist1, a transcription factor that drives endothelial-to-mesenchymal transition, in plaque progression by inducible deletion from endothelial cells in hypercholesterolemic mice (Twist1

Indexed as

Endothelial-Mesenchymal TransitionNuclear ProteinsPlaque, AtheroscleroticTwist-Related Protein 1AnimalsAortaAtherosclerosisCell MovementCell ProliferationCollagen Type IVEndothelial CellsHumansMaleMiceTranscription FactorsCollagen Type IVNuclear ProteinsTranscription FactorsTWIST1 protein, humanTwist1 protein, mouseTwist-Related Protein 1

Identifiers

PMID41708636
PMCPMC13031644

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.