Evidence map›Paper›PMID 41708332›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Vesicular Glutamate Release Is Necessary for Neural Tube Formation.

Raman Goyal, Patricio A Castro, Jacqueline B Levin, Sangwoo Shim, Olga A Balashova, Alexios A Panoutsopoulos, Nicolas A Fuentes, Grace Or Mizuno, Lin Tian, Laura N Borodinsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Raman GoyalDepartment of Physiology & Membrane Biology, Shriners Hospitals for Children Northern California, University of California Davis, School of Medicine, Sacramento, California.
Patricio A CastroDepartment of Physiology & Membrane Biology, Shriners Hospitals for Children Northern California, University of California Davis, School of Medicine, Sacramento, California.
Jacqueline B LevinDepartment of Physiology & Membrane Biology, Shriners Hospitals for Children Northern California, University of California Davis, School of Medicine, Sacramento, California.
Sangwoo ShimDepartment of Physiology & Membrane Biology, Shriners Hospitals for Children Northern California, University of California Davis, School of Medicine, Sacramento, California.
Olga A BalashovaDepartment of Physiology & Membrane Biology, Shriners Hospitals for Children Northern California, University of California Davis, School of Medicine, Sacramento, California.
Alexios A PanoutsopoulosDepartment of Physiology & Membrane Biology, Shriners Hospitals for Children Northern California, University of California Davis, School of Medicine, Sacramento, California.
Nicolas A FuentesLaboratory of Neural Development, LAND, Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción 4030000, Chile.ORCID 0009-0004-5337-0731
Grace Or MizunoDepartment of Biochemistry & Molecular Medicine, University of California Davis, School of Medicine, Sacramento, California.
Lin TianDepartment of Biochemistry & Molecular Medicine, University of California Davis, School of Medicine, Sacramento, California.
Laura N BorodinskyDepartment of Physiology & Membrane Biology, Shriners Hospitals for Children Northern California, University of California Davis, School of Medicine, Sacramento, California lnborodinsky@ucdavis.edu.ORCID 0000-0003-2937-7023

Funding

Mechanisms of folate action during nervous system developmentR01NS105886 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Laura Noemi Borodinsky · 2019 to 2026
$2.5M
Mechanisms of neural activity during neural tube formationR01NS113859 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BORODINSKY, LAURA NOEMI · 2020 to 2024
$2.1M
NINDS NIH HHS R01 NS105886NINDS NIH HHS R01 NS113859
6 · The paper itself

Abstract

The brain and spinal cord originate from a neural tube that is preceded by a flat structure known as the neural plate during early embryogenesis. In humans, failure of the neural plate to convert into a tube by the fourth week of pregnancy leads to neural tube defects (NTDs), birth defects with serious neurological consequences. The signaling mechanisms governing the process of neural tube morphogenesis are unclear. Here we show that in

Indexed as

Glutamic AcidNeural TubeVesicular Glutamate Transport Protein 1AnimalsCalciumCell ProliferationFemaleNeural PlateNeural Stem CellsNeural Tube DefectsXenopus laevisCalciumGlutamic AcidVesicular Glutamate Transport Protein 1calcium transientsglutamate releaseneural stem cell proliferationneural tube formation

Identifiers

PMID41708332
PMCPMC12988593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.