Evidence map›Paper›PMID 41708227›Full record

ReviewClinics in perinatology2026

Genetics and Stillbirth.

Tsegaselassie Workalemahu, Monica H Wojcik

Abstract readReview
In one paragraph

Review in Clinics in perinatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tsegaselassie WorkalemahuDepartment of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT, USA. Electronic address: u6026132@umail.utah.edu.
Monica H WojcikDivisions of Newborn Medicine & Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.

Funding

Inherited and de novo genetic variants relevant to familial, recurrent and sporadic stillbirthR01HD112836 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Tsegaselassie Workalemahu · 2023 to 2026
$2.5M
NICHD NIH HHS R01 HD112836
6 · The paper itself

Abstract

Stillbirth affects over 3 million pregnancies globally and remains unexplained in roughly half of US cases. Genetic testing has uncovered chromosomal causes in approximately 6% to 13% of stillbirths, while exome sequencing has identified Mendelian variants in an additional approximately 5% to 10%. Family-based genome sequencing may allow identification of inherited and de novo pathogenic variants with increased diagnostic yield. We reviewed current knowledge ranging from rare monogenic disorders and polygenic risk to epigenetic dysregulation contributing to stillbirth. We provide a clinical framework aimed at refining stillbirth diagnosis toward improved clinical management of stillbirth in future pregnancies.

Indexed as

StillbirthExome SequencingFemaleGenetic TestingHumansPregnancyAutopsyChromosomal microarrayExome sequencingGenome sequencingInheritedStillbirth

Identifiers

PMID41708227
PMCPMC13222042

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.