Evidence map›Paper›PMID 41708119›Full record

ArticleEuropean respiratory review : an official journal of the European Respiratory Society2026

Pulmonary diffusing capacity for nitric oxide in disease: a scoping review.

Thomas Radtke, Hà Pham-Ngoc, Thong Hua-Huy, Connie C W Hsia, Holger Dressel, Anh Tuan Dinh-Xuan

Abstract readScoping Review
In one paragraph

Article in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas RadtkeDivision of Occupational and Environmental Medicine, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland thomas.radtke@uzh.ch.ORCID https://orcid.org/0000-0002-1723-1070
Hà Pham-NgocService de Physiologie-Explorations Fonctionnelles, AP-HP, Hôpital Cochin, Université Paris Cité, Paris, France.
Thong Hua-HuyService de Physiologie-Explorations Fonctionnelles, AP-HP, Hôpital Cochin, Université Paris Cité, Paris, France.
Connie C W HsiaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Holger DresselDivision of Occupational and Environmental Medicine, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Anh Tuan Dinh-XuanService de Physiologie-Explorations Fonctionnelles, AP-HP, Hôpital Cochin, Université Paris Cité, Paris, France.ORCID https://orcid.org/0000-0001-8651-5176

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis scoping review aims to map the available studies on single-breath pulmonary diffusing capacity for nitric oxide (

methodsWe followed the JBI methodology for scoping reviews. A systematic literature search was conducted in Embase, MEDLINE (EBSCOhost), PubMed, Scopus, Web of Science and the Cochrane Library to identify studies on

resultsWe identified 1638 studies, of which 69 met the eligibility criteria. These studies represented respiratory (n=22), immunological/genetic/systemic (n=14), post-COVID-19 sequelae (n=13), cardiovascular (n=9), metabolic/endocrine/renal (n=6), environmental-related (n=3) and other (n=2) conditions. There was substantial heterogeneity in disease categories, sample sizes and reporting methods. Nearly half of the studies (49.3%) used convenience sampling, where participant selection processes are often poorly described; 62.3% included <50 participants. Only 18.8% reported a sample size calculation, and 10.1% registered or published a study protocol. Disparate findings within disease categories were often difficult to interpret; and small sample sizes limited generalisability. In some specific conditions,

conclusionSingle-breath

Indexed as

COVID-19LungLung DiseasesNitric OxidePulmonary Diffusing CapacityHumansPredictive Value of TestsNitric Oxide

Identifiers

PMID41708119
PMCPMC12914377

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.