Evidence map›Paper›PMID 41708115›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Familial Mediterranean Fever Presenting with Recurrent Abdominal Pain without Periodic Fever Following COVID-19.

Nobuhiro Ueno, Hiromichi Sugai, Suzumi Ujiie, Ryunosuke Hayashi, Kazuki Dai, Manami Hayashi, Yu Kobayashi, Yuki Murakami, Aki Sakatani, Keitaro Takahashi and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Nobuhiro UenoDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Hiromichi SugaiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Suzumi UjiieDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Ryunosuke HayashiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Kazuki DaiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Manami HayashiDepartment of Diagnostic Pathology, Asahikawa Medical University Hospital, Japan.
Yu KobayashiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Yuki MurakamiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Aki SakataniDepartment of Gastroenterological Sciences, Asahikawa Medical University, Japan.
Keitaro TakahashiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Tatsuya DokoshiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Katsuyoshi AndoDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Shin KashimaDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Kentaro MoriichiDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Hiroki TanabeDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.
Mishie TaninoDepartment of Diagnostic Pathology, Asahikawa Medical University Hospital, Japan.
Mikihiro FujiyaDivision of Gastroenterology, Department of Medicine, Asahikawa Medical University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial Mediterranean fever (FMF) rarely presents without a periodic fever. We report the case of a 16-year-old girl who developed recurrent abdominal pain after coronavirus disease 2019 without fever. The initial evaluation, including endoscopy, was unremarkable, except for mildly elevated fecal calprotectin (182.1 μg/g). On readmission, peritoneal signs, mild pleural effusion, and elevated serum amyloid A (113.9 mg/L) were noted, while the C-reactive protein level remained normal. Colchicine promptly suppressed these attacks. MEFV sequencing revealed a homozygous E148Q mutation, supporting an atypical FMF. Fecal calprotectin and serum amyloid A levels normalized within one month. This case underscores the importance of FMF in post-infectious recurrent abdominal pain and highlights targeted biomarkers and genetics for making a timely diagnosis.

Indexed as

Abdominal PainCOVID-19Familial Mediterranean FeverAdolescentColchicineFemaleFeverHumansMutationPyrinRecurrenceColchicineMEFV protein, humanPyrinatypicalCOVID-19E148Qfamilial mediterranean feverMEFV

Identifiers

PMID41708115
PMCPMC13668780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.