ArticleInternal medicine (Tokyo, Japan)2026
Acute Muscle Injury and Subcutaneous Edema in a Patient with Anti-nuclear Matrix Protein-2 Antibody Positive Dermatomyositis Sine Dermatitis.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This case describes anti-nuclear matrix protein-2 (NXP-2) antibody-positive dermatomyositis sine dermatitis (DMSD) with an acute onset and marked creatine kinase (CK) elevation, closely mimicking drug-induced rhabdomyolysis. The patient lacked a skin rash and initially improved with hydration, but later developed respiratory failure, leading to a diagnosis via a muscle biopsy and antibody testing. Notably, the imaging findings also resembled rhabdomyolysis, further complicating differentiation. This case highlights that when anti-NXP-2-positive myositis presents as DMSD with acute, transient CK elevation and rhabdomyolysis-like imaging, however, distinguishing between these two conditions is extremely difficult. In such atypical cases, a muscle biopsy plays a critical role and should be actively considered for the diagnosis.
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