Evidence map›Paper›PMID 41708012›Full record

ReviewProgress in retinal and eye research2026

Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation.

Whitney Stuard Sambhariya, Catherine Bowes Rickman, Patricia A D'Amore, Giulia Corradetti, Gregory S Hageman, Gareth R Howell, Olivia J Marola, Hemali Phatnani, Nancy J Philp, Debasish Sinha and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in retinal and eye research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Whitney Stuard SambhariyaWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, USA.
Catherine Bowes RickmanDepartment of Ophthalmology and of Cell Biology, Duke University, Durham, NC, USA.
Patricia A D'AmoreDepartment of Ophthalmology, Harvard University, Boston, MA, USA.
Giulia CorradettiDepartment of Ophthalmology David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Gregory S HagemanSteele Center for Translational Medicine, John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, Utah, USA.
Gareth R HowellThe Jackson Laboratory, Bar Harbor, ME, USA.
Olivia J MarolaThe Jackson Laboratory, Bar Harbor, ME, USA.
Hemali PhatnaniDepartment of Neurology, Columbia University, New York City, NY USA.
Nancy J PhilpDepartment of Pathology & Genomic Medicine, Jefferson College of Life Sciences, Philadelphia, PA, USA.
Debasish SinhaWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, USA.
Christopher B ToomeyDepartment of Ophthalmology, University of California, San Diego, CA, USA.
Faith StoneWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, USA.
Charles EberhartWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, USA.
James T HandaWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, USA. Electronic address: jthanda@jhmi.edu.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
VCID CWOW: Identifying Novel Targets to Treat Cerebral Amyloid AngiopathyRF1NS139948 · NINDS · JACKSON LABORATORY · PI HOWELL, GARETH R, SEYFRIED, NICHOLAS THOMAS · 2024 to 2024
$5.9M
Complement factor H modulates lipoprotein clearance in AMDR01EY031748 · NEI · DUKE UNIVERSITY · PI BOWES RICKMAN, CATHERINE · 2020 to 2024
$2.8M
Targeting lysosome/RPE heterogeneity in AMD pathobiology as a novel therapyR01EY031594 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDA, JAMES T, SINHA, DEBASISH · 2021 to 2024
$2.4M
Does age/stress-induced mitochondrial dysfunction induce variations in RPE phenotype in AMD?R01EY035805 · NEI · TULANE UNIVERSITY OF LOUISIANA · PI James T Handa, Shusheng Wang · 2024 to 2026
$1.9M
The role of epigenetics in RPE heterogeneity with early AMDR01EY033765 · NEI · JOHNS HOPKINS UNIVERSITY · PI HANDA, JAMES T · 2022 to 2025
$1.8M
Gene therapy targeting CFH and lipoprotein dynamics in AMDR01EY037682 · NEI · DUKE UNIVERSITY · PI CATHERINE BOWES RICKMAN · 2025 to 2026
$1.4M
Solute Transporters and Retinal HealthR01EY035772 · NEI · THOMAS JEFFERSON UNIVERSITY · PI NEAL S. PEACHEY, NANCY Jean PHILP · 2025 to 2026
$1.2M
Role of Bruch Membrane Heparan Sulfate in Drusenogenesis in Age-Related Macular DegenerationK08EY035322 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christopher B Toomey · 2024 to 2026
$764k
Bruch's Membrane-On-A-Chip to Study Drusen Formation in AMDR21EY037260 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TOOMEY, CHRISTOPHER B · 2025 to 2025
$639k
NEI NIH HHS K08 EY035322NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY031594NEI NIH HHS R01 EY031748NEI NIH HHS R01 EY033765NEI NIH HHS R01 EY035772NEI NIH HHS R01 EY035805NEI NIH HHS R01 EY037682NEI NIH HHS R21 EY037260NINDS NIH HHS RF1 NS139948
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) and Alzheimer's disease (AD) are neurodegenerative conditions that afflict millions of elderly people around the world. AMD is a progressive retinal disorder that leads to central vision loss whereas AD primarily causes cognitive decline and behavioral changes. While each disease has distinct clinical manifestations, the accumulation of extracellular amyloid-β is a common histopathologic finding. Similarly, cerebral amyloid angiopathy (CAA), a vascular condition that can exist independent or with AD, is characterized by the accumulation of amyloid-β in cerebral blood vessels. While significant investigation of the pathophysiologic links between AMD and AD has been conducted, the underlying similarities and differences in the pathobiology of AMD and CAA has not been considered. In this review, we discuss the common pathological features of these two conditions. We then discuss the similar pathobiology that involves cholesterol metabolism, apolipoprotein E, amyloid-β, and complement mediated inflammation. At the same time, we discuss key differences in their pathobiology. This discussion sheds new perspective and insights of their pathobiology.

Indexed as

Amyloid beta-PeptidesApolipoproteins ECerebral Amyloid AngiopathyCholesterolComplement System ProteinsInflammationMacular DegenerationAnimalsHumansAmyloid beta-PeptidesApolipoproteins ECholesterolComplement System ProteinsAge-related macular degenerationAlzheimer's diseaseAmyloid-βCerebral amyloid angiopathyDrusenRetinal pigment epithelium

Identifiers

PMID41708012
PMCPMC12949356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.