Evidence map›Paper›PMID 41708004›Full record

ArticleThe Journal of biological chemistry2026

Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1.

Francisco G Sanchez-Conde, Matthew R Goodrich, Olivia M Stack, Louis N R Goldberg, Pamela K Ruzycki, Abhilasha Jain, Eric N Jimenez-Vazquez, David K Jones

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Francisco G Sanchez-CondeDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Matthew R GoodrichDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Olivia M StackDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Louis N R GoldbergDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Pamela K RuzyckiDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Abhilasha JainDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Eric N Jimenez-VazquezDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
David K JonesDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: davekj@umich.edu.

Funding

A hERG1 potassium channel subdomain is trafficked to the cardiac nucleus: mechanisms and targets of the hERG1NPR01HL171039 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David K. Jones · 2024 to 2026
$1.4M
Probing mechanisms of long QT type 2-associated neuronal dysfunction using gene-edited stem cell-derived neuronsR21NS136833 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David K. Jones · 2025 to 2026
$429k
NHLBI NIH HHS R01 HL171039NINDS NIH HHS R21 NS136833
6 · The paper itself

Abstract

Human Ether-à-go-go-Related Gene 1 (hERG1) nuclear peptide (hERG1

Indexed as

Cell NucleusDeath, Sudden, CardiacERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsHEK293 CellsHumansERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsKCNH2 protein, humanhERGion channelKCNH2SIDSSUDEP

Identifiers

PMID41708004
PMCPMC12995837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.