ArticleAdvances in medical sciences2026
Transforming growth factor-β1 downregulates tryptophanyl-tRNA synthetase expression in human lung fibroblasts.
Article in Advances in medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe role of tryptophanyl-tRNA synthetase, also known as WARS, in lung fibroblasts is currently unknown. We aimed to study the effect of transforming growth factor-beta 1 (TGF-β1) on the expression of WARS and whether it regulates profibrotic responses in TGF-β1-activated human lung fibroblasts. MATERIALS AND
methodsWe used MRC-5, a human lung fibroblast cell line, and primary human lung fibroblasts (HLFs) derived from control subjects. WARS expression was measured by enzyme-linked immunosorbent assay (ELISA) and Western blot. Profibrotic responses in TGF-β1-stimulated human lung fibroblasts were measured by Western blot, gel contraction assay, and real-time quantitative PCR (RT-qPCR).
resultsWe demonstrate that TGF-β1 potently downregulates WARS expression, both at the extracellular and intracellular levels, in MRC-5, and HLFs. Yin Yang 1 (YY1) transcription factor (TF) silencing ameliorates the inhibitory effect of TGF-β1 on WARS expression. Finally, we found that recombinant (r) WARS significantly inhibited fibronectin (FN) but had no effect on collagen1 (COL1) or alpha-smooth muscle actin (αSMA) expression in TGF-β1-induced HLFs.
conclusionsOur results demonstrate that TGF-β1 inhibits WARS expression via YY1, however, WARS treatment has a modest effect on regulating profibrotic responses in activated HLFs.
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