Evidence map›Paper›PMID 41707652›Full record

ArticleCell reports. Medicine2026

Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome.

Joni Näsiaho, Linda Nissi, Sami Ventelä, Heikki Irjala, Marko Salmi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joni NäsiahoMediCity Research Laboratory, University of Turku, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.
Linda NissiDepartment of Otorhinolaryngology, University of Turku and Turku University Hospital, Turku, Finland.
Sami VenteläDepartment of Otorhinolaryngology, University of Turku and Turku University Hospital, Turku, Finland; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Heikki IrjalaDepartment of Otorhinolaryngology, University of Turku and Turku University Hospital, Turku, Finland.
Marko SalmiMediCity Research Laboratory, University of Turku, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address: marko.salmi@utu.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to 20% of patients with early-stage oral squamous cell carcinoma (OSCC) develop postoperative relapse, but no parameters currently enable the identification of individuals with poor prognosis. Here, we report a spatially resolved single-cell analysis of the tumor microenvironment in OSCC. By analyzing >700,000 cells for 25 proteins using imaging mass cytometry, we discover leukocyte and endothelial cell phenotypes that are independent prognostic factors for survival. Most notably, the presence of proliferating lymphatic endothelial cells (KI67

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsSingle-Cell AnalysisTumor MicroenvironmentBiomarkers, TumorFemaleHumansMaleNeoplasm Recurrence, LocalPrognosisBiomarkers, Tumorbiomarkerslymphatic vesselsspatial single-cell proteomicstongue carcinomatumor microenvironment

Identifiers

PMID41707652
PMCPMC12923947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.