Evidence map›Paper›PMID 41707650›Full record

Trial reportCell reports. Medicine2026

Establishing a standard surgery for esophagogastric junction cancer: Final results from the JGCA-JES nationwide prospective study.

Yukinori Kurokawa, Hiroya Takeuchi, Yuichiro Doki, Shinji Mine, Masanori Terashima, Takushi Yasuda, Kazuhiro Yoshida, Hiroyuki Daiko, Shinichi Sakuramoto, Takaki Yoshikawa and 6 more

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Therapeutic value of para-aortic lymph node dissection in gastric cancer with extensive lymph node metastasis: integrated analysis of three phase II trials (JCOG2212A).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yukinori KurokawaDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Osaka, Japan. Electronic address: ykurokawa@gesurg.med.osaka-u.ac.jp.
Hiroya TakeuchiDepartment of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan; Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Shinji MineDepartment of Surgery, Cancer Institute Hospital, Tokyo, Japan.
Masanori TerashimaDepartment of Gastric Surgery, Shizuoka Cancer Center, Mishima, Japan.
Takushi YasudaDepartment of Surgery, Kindai University Faculty of Medicine, Osaka, Japan.
Kazuhiro YoshidaDepartment of Gastroenterological and Pediatric Surgery, Gifu University School of Medicine, Gifu, Japan.
Hiroyuki DaikoDepartment of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Shinichi SakuramotoDepartment of Gastroenterological Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Takaki YoshikawaDepartment of Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Chikara KunisakiDepartment of Surgery, Yokohama City University Gastroenterological Center, Yokohama, Japan.
Yasuyuki SetoDepartment of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan.
Shigeyuki TamuraDepartment of Surgery, Kansai Rosai Hospital, Amagasaki, Japan.
Toshio ShimokawaDepartment of Biostatistics, Faculty of Medicine Wakayama Medical University, Wakayama, Japan.
Takeshi SanoDepartment of Surgery, Cancer Institute Hospital, Tokyo, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The optimal surgical approach and extent of lymph node dissection for esophagogastric junction (EGJ) cancer remains uncertain. We conduct a nationwide multicenter prospective study in patients with resectable cT2-T4 adenocarcinoma or squamous cell carcinoma with the tumor epicenter located within 2 cm of the EGJ. Patients undergo subtotal or lower esophagectomy with dissection of all regional lymph nodes. Of 1,065 patients screened, 371 are enrolled before surgery. Final analysis shows that proximal perigastric and suprapancreatic nodes exhibit a high therapeutic efficacy index (TEI), strongly supporting their dissection for improved long-term survival. TEIs in middle and lower para-esophageal stations are higher when esophageal involvement exceeds 3 and 2 cm, respectively. Conversely, all other stations, including distal perigastric and paraaortic nodes, have low TEIs, indicating minimal survival impact. Thus, mediastinal node dissection should be tailored to esophageal involvement length. This study is registered at UMIN Clinical Trials Registry (UMIN000013205).

Indexed as

AdenocarcinomaCarcinoma, Squamous CellEsophageal NeoplasmsEsophagectomyEsophagogastric JunctionAgedFemaleHumansLymph Node ExcisionMaleMiddle AgedProspective Studiesesophageal invasion lengthesophageal involvement lengthesophagogastric junction cancergastroesophageal junction cancerNishi classificationright transthoracic approachSiewert classificationtherapeutic efficacy indextherapeutic value indextranshiatal approach

Identifiers

PMID41707650
PMCPMC12923963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.