Evidence map›Paper›PMID 41707635›Full record

ArticleUltrasonics sonochemistry2026

Intensification of Palmaria palmata protein biorefinery using multifrequency ultrasonication and enzymes.

Oscar M Elizondo Sada, Romano W J C van Bers, Rene H Wijffels, Wouter J J Huijgen, Antoinette Kazbar, Iulian Z Boboescu

Abstract read
In one paragraph

Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oscar M Elizondo SadaBioprocess Engineering, Wageningen University & Research, PO Box 16 Wageningen 6700 AA, the Netherlands.
Romano W J C van BersBioprocess Engineering, Wageningen University & Research, PO Box 16 Wageningen 6700 AA, the Netherlands.
Rene H WijffelsBioprocess Engineering, Wageningen University & Research, PO Box 16 Wageningen 6700 AA, the Netherlands; Nord University, Faculty of Biosciences and Aquaculture, Bodo N8049, Norway.
Wouter J J HuijgenBioprocess Engineering, Wageningen University & Research, PO Box 16 Wageningen 6700 AA, the Netherlands.
Antoinette KazbarBioprocess Engineering, Wageningen University & Research, PO Box 16 Wageningen 6700 AA, the Netherlands.
Iulian Z BoboescuBioprocess Engineering, Wageningen University & Research, PO Box 16 Wageningen 6700 AA, the Netherlands. Electronic address: iulian.boboescu@wur.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The red seaweed Palmaria palmata is a promising source for alternative proteins. Development of mild and novel biorefinery approaches are needed for green processes yielding functional proteins. Process intensification using ultrasound-assisted unit operations can be an effective strategy to circumvent current seaweed biorefinery challenges, in particular limited protein extraction yields. In this research, first, effects of acoustic cavitation (AC) during ultrasound-assisted extraction (UAE) were studied using a multifactorial design of experiments for total protein and R-phycoerythrin (RPE) extraction from P. palmata. Secondly, novel enzyme-assisted high-frequency ultrasonic extraction (EAUE) was developed following the same approach and responses. Contrary to the traditional acoustic cavitation process, this intensification strategy allows a milder extraction of proteins from the recalcitrant P. palmata harnessing combined effects of acoustic irradiation and enzymes. Validation experiments showed the robustness of developed models. Maximum RPE yields were 2.6 mg/g

Indexed as

Chemical FractionationPlant ProteinsRhodophytaSonicationUltrasonic WavesEdible SeaweedsPhycoerythrinPhycoerythrinPlant ProteinsAcoustic cavitationenzyme-assisted ultrasound extraction (EAUE)R-phycoerythrinSeaweed biorefinerySonoprocessUltrasound-assisted extraction (UAE)

Identifiers

PMID41707635
PMCPMC12930171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.