Observational studyBurns : journal of the International Society for Burn Injuries2026
Analysis of treatment pathways and long-term prevalence of pruritus after burn - An observational study with real-world data.
Observational study in Burns : journal of the International Society for Burn Injuries, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionBurns heal with long-lasting scars and complications, such as persistent pruritus. To date, there is no consensus on optimal treatment. This study aims to identify prevalence and treatment patterns of burn-related pruritus using a large dataset.
methodsA retrospective cohort study was conducted using the real-world database TriNetX. Burn patients were identified and stratified into three cohorts by extent of total body surface area (TBSA) burned: Cohort 1 (<20 %; mild), Cohort 2 (20-39 %; moderate), and Cohort 3 (≥40 %; severe). Prevalence of pruritus, eosinophilia status, and treatment patterns were assessed. Age group and temporal effects were tested using Chi-square.
resultsWe identified 257,360 burn patients with a mean age of 37 ± 23 years. Pruritus prevalence ranged from 3.29 % to 7.95 % in paediatric patients and from 1.50 % to 9.75 % in adult patients. Peak prevalence occurred in those with 20-39 % TBSA burned, aged 41-60 years, and within 3 years after burn. Severe eosinophilia peaked in 41-60-year-olds with burns > 40 % of TBSA. The most commonly prescribed drug classes across all cohorts were H1-antihistamines, 5-HT3 receptor antagonists, and neuropathic pain drugs.
conclusionOur real-world database analysis indicates that the prevalence of post-burn pruritus varies by age and burn size, showing a tendency to decrease with age but increase over time. The highest prevalence was observed in patients with moderate-sized burns (20-39 % TBSA burned). Treatment patterns remain inconsistent, underscoring the need for standardized and evidence-based strategies.
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