Evidence map›Paper›PMID 41707281›Full record

ArticleEuropean journal of medicinal chemistry2026

Design, synthesis, and characterization of F-18 sigma-1 receptor radiotracers for Alzheimer disease.

Hao Jiang, Sandip B Jadhav, Anil Kumar Soda, Wenjuan Zhou, Hong Chen, Shuxian Xu, Lin Qiu, Tianyu Huang, Zhimin Xing, Lei Zhao and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hao JiangDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Sandip B JadhavDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Anil Kumar SodaDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Wenjuan ZhouDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Hong ChenDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Shuxian XuDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Lin QiuDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Tianyu HuangDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Zhimin XingDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Lei ZhaoDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA.
John J LeeDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA.
Ruiqing NiInstitute for Regenerative Medicine, University of Zurich, Institute for Biomedical Engineering, University of Zurich & ETH Zurich, Zurich, Switzerland; Department of Nuclear Medicine, Inselspital University Hospital Bern, Bern, Switzerland.
Dean F WongDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Currently at Department of Neurosurgery and Kahlert Institute of Addiction Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Guangyong PengDepartment of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA.
Joel S PerlmutterDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Departments of Neurology, Neuroscience, and Programs in Occupational Therapy and Physical Therapy, Washington University School of Medicine, St Louis, MO, 63110, USA.
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA.
Zhude TuDepartment of Radiology, Washington University School of Medicine, St Louis, MO, 63110, USA. Electronic address: zhudetu@wustl.edu.

Funding

PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R33MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2013 to 2015
$1.5M
Acquisition of high-resolution PET/CT preclinical imaging instrument at MIRS10OD030403 · OD · WASHINGTON UNIVERSITY · PI SHOGHI, KOORESH ISAAC · 2021 to 2021
$929k
DEVELOPMENT OF VESICULAR ACETYLCHOLINE TRANSPORTER IMAGING AGENTS FOR PETR21NS061025 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2009 to 2010
$628k
DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)R21MH092797 · NIMH · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2012
$530k
NIH HHS S10 OD030403NIMH NIH HHS R21 MH092797NIMH NIH HHS R33 MH092797NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS134586NINDS NIH HHS R21 NS061025
6 · The paper itself

Abstract

Sigma-1 receptor (σ

Indexed as

Alzheimer DiseaseDrug DesignFluorine RadioisotopesRadiopharmaceuticalsReceptors, sigmaAnimalsBrainHumansMiceMice, TransgenicMolecular StructurePositron-Emission TomographySigma-1 ReceptorTissue DistributionFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsReceptors, sigmaSigma-1 Receptor3xTg-AD mouseAlzheimer diseaseF-18 radiotracersNonhuman primatePET imagingSigma-1 receptor (σ(1)R)

Identifiers

PMID41707281
PMCPMC13546073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.