ArticleInflammatory bowel diseases2026
Characterization of mesocolic adipose hyperplasia in a rat 2,4,6-trinitrobenzenesulfonic acid colitis model and comparison to creeping fat in Crohn disease.
Article in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
Abstract
backgroundCreeping fat (CrF) has emerged as a key pathological feature of Crohn disease (CD). Available data suggest that microbial translocation in CD may trigger CrF development, potentially exacerbating intestinal inflammation and disrupting homeostasis. However, the role of CrF in disease progression remains poorly understood, raising the need for experimental models.
methodsColitis was induced using 2,4,6-trinitrobenzenesulfonic acid (TNBS) in Sprague-Dawley rats kept in conventional housing conditions. Colonoscopy and weight follow-up observations were performed 3 and 5 days after colitis induction. Samples were collected at day 5 for histopathological staining and cytokine gene expression analyses.
resultsMesocolic adipose hyperplasia resembling CrF-like mesentery was present in both male and female TNBS-treated rats, with no significant sex-related variation in prevalence. Endoscopic evaluation revealed that only TNBS-treated rats with a colonoscopic score greater than 7 (out of 9) exhibited a significant presence of a CrF-like mesentery. Furthermore, a strong correlation was observed between the severity of colonic inflammation and the presence of CrF-like mesentery, including hyperplastic adipocytes, increased immune cell infiltration, and fibrosis. Molecular characterization showed an upregulation of key inflammatory cytokines-interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α-and the pathogen-recognition receptors-Toll-like receptor 2 (TLR2) and nucleotide-binding oligomerization domain-containing protein 2 (NOD2)-in the CrF-like mesocolon, as observed in human CrF. Finally, animals exhibiting CrF-like mesocolon showed a translocation of Gram-positive cocci in the subserosal layer.
conclusionsMesocolic hyperplasia, closely replicating the key histopathological and molecular features of CD-related CrF, developed in half of the rats in this model. This model provides a cost-effective platform for studying the interplay between intestinal inflammation and mesenteric adipose tissue remodeling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.