Trial reportAmerican journal of physical medicine & rehabilitation2026
Repetitive Transcranial Magnetic Stimulation of the Contralesional Dorsal Premotor Cortex for Upper Extremity Motor Improvement in Severe Stroke: A Pilot Randomized Clinical Trial.
Trial report in American journal of physical medicine & rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- TMS-Derived Neurophysiological Measures of Corticospinal Excitability, Intracortical Excitability, and Interhemispheric Interactions Associated With Post-Stroke Motor Recovery: A Systematic Review.The European journal of neuroscience · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
objectiveThe aim of the study was to compare the effects of repetitive transcranial magnetic stimulation targeting the contralesional dorsal premotor versus the ipsilesional primary motor cortex in chronic stroke survivors with severe hand paresis.
designThis assessor-blinded pilot randomized trial enrolled 16 participants ≥6 mos after stroke with severe hand paresis, defined by the absence of either 10° distal extension in wrist/fingers/thumb or motor evoked potentials in paretic muscles. Participants received 5-Hz repetitive transcranial magnetic stimulation to the contralesional dorsal premotor or the ipsilesional primary motor cortex target, combined with upper extremity rehabilitation for 6 wks. Outcomes included Upper Extremity Fugl-Meyer, Wolf Motor Function Test, Stroke Impact Scale-16, and interhemispheric inhibition.
resultsBaseline characteristics were similar across groups, although the ipsilesional stimulation group had more participants with motor evoked potentials and ≥10° thumb extension (P = 0.04). Both groups achieved similar gains on Fugl-Meyer, but wrist subscore changes favored the ipsilesional stimulation group (P = 0.011). No differences were observed for other outcomes.
conclusionsStimulation of the contralesional dorsal premotor cortex was not superior to stimulation of the ipsilesional primary motor cortex for upper extremity rehabilitation outcomes in chronic stroke survivors with severe hand paresis, though both approaches yielded sustained motor improvements. Future trials should stratify by distal extension and physiology.
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Registered trials
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