Evidence map›Paper›PMID 41707065›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Gpr75 Deletion in Adipocytes Protects From Diet-Induced Obesity: Changes in Glucose Homeostasis and Inflammatory Responses.

Sakib Hossain, Elizabeth Villegas, Catherine Liapes, Nahid Sultana, Dorina Krasniqi, Danielle Diegisser, Ana Castro, Comfort Williams, Artiom Gruzdev, Darryl C Zeldin and 2 more

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sakib HossainDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Elizabeth VillegasDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Catherine LiapesDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Nahid SultanaDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Dorina KrasniqiDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Danielle DiegisserDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Ana CastroDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Comfort WilliamsDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Artiom GruzdevNational Institute of Environmental Health Sciences, National Institutes of Health, North Carolina, USA.
Darryl C ZeldinNational Institute of Environmental Health Sciences, National Institutes of Health, North Carolina, USA.
Victor GarciaDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Michal Laniado SchwartzmanDepartment of Pharmacology, School of Medicine, New York Medical College, Valhalla, New York, USA.ORCID https://orcid.org/0000-0003-0254-7248

Funding

National Institutes of Health (NIH) HL139793National Institutes of Health (NIH) TR004478
6 · The paper itself

Abstract

Loss of function G-protein coupled receptor 75 (GPR75) variants in humans are associated with leanness, and Gpr75 null mice are protected from diet-induced obesity (DIO). However, the mechanisms underlying this protection are largely unknown. Here, we investigated the contribution of adipocyte-derived Gpr75 to DIO. Adipocyte-specific Gpr75 knockout (adipo-Gpr75

Indexed as

AdipocytesDiet, High-FatGlucoseHomeostasisInflammationObesityReceptors, G-Protein-CoupledAnimalsEnergy MetabolismFemaleMaleMiceMice, Inbred C57BLMice, KnockoutGlucoseReceptors, G-Protein-CoupleddiabetesGLP‐1GPR75insulin sensitivityobesitysex differences

Identifiers

PMID41707065
PMCPMC12916076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.