Evidence map›Paper›PMID 41706891›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

β

Harshita Agarwal, Harita Ben, Amlan Chaini, Bharat Gurnani, Nabanita Mukherjee, Arumay Pal, Arun Kumar Upadhyaya, Surajit Ghosh, Dibyendu Kumar Sasmal, Neha Jain

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Harshita AgarwalDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Jodhpur, Karwar 342030, India.ORCID 0009-0009-0801-4101
Harita BenDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Jodhpur, Karwar 342030, India.ORCID 0009-0000-9110-4494
Amlan ChainiDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Jodhpur, Karwar 342030, India.ORCID 0009-0001-5156-1663
Bharat GurnaniCentre of Excellence-AyurTech, Indian Institute of Technology, Jodhpur, Karwar, Rajasthan 342030, India.ORCID 0000-0002-6441-6377
Nabanita MukherjeeSmart Healthcare, Interdisciplinary Research Division, Indian Institute of Technology, Jodhpur, Karwar 342030, India.ORCID 0000-0002-0228-5148
Arumay PalSchool of Biosciences, Engineering and Technology, Vellore Institute of Technology, Bhopal 60607, India.ORCID 0000-0001-5566-6035
Arun Kumar UpadhyayaDepartment of Chemistry, Indian Institute of Technology, Jodhpur, Karwar 342030, India.ORCID 0000-0001-9920-9928
Surajit GhoshDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Jodhpur, Karwar 342030, India.ORCID 0000-0002-8203-8613
Dibyendu Kumar SasmalDepartment of Chemistry, Indian Institute of Technology, Jodhpur, Karwar 342030, India.
Neha JainDepartment of Bioscience and Bioengineering, Indian Institute of Technology, Jodhpur, Karwar 342030, India.ORCID 0000-0001-6269-5619

Funding

Academy of Scientific and Innovative Research (AcSIR) ANRF/CRG/2023/003083Council of Scientific and Industrial Research, India (CSIR) 37WS(0014)/2023-24/EMR-II/ASPIREEuropean Molecular Biology Organization (EMBO) T/EMBO/NJ/20230244Indian Institute of Technology Jodhpur (IITJ) I/Seed/NJ/20190019MOHFW | DHR | Indian Council of Medical Research (ICMR) IIRPSG-2024-01-07063Scheme for Transformational and Advanced Research in Sciences STARS2/2023-0473Technology Innovation Hub project TIH/iHUB Drishti/Project/2021-22/21आयुष मंत्रालयCentral Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India (CCRAS) S-12011/12/2021-SCHEME
6 · The paper itself

Abstract

Bacteria have evolved a remarkable strategy to thrive in hostile environments by creating well-organized microcommunities known as biofilms. Biofilms pose a serious global health challenge due to their contribution to antibiotic resistance and suppression of the effectiveness of immune responses, thereby exacerbating pathogenic conditions. Biofilm-dwelling bacteria are difficult to eliminate since the cells are embedded within a self-produced, intricate 3D extracellular matrix composed of protein polymers (amyloids), polysaccharides, and extracellular nucleic acids. The robustness of the matrix poses a significant challenge to curb biofilm infections. Moreover, there is a lacuna in understanding how biofilm may be controlled under physiological conditions. Therefore, it is imperative to investigate the role of host proteins in keeping a check on biofilm formation. In the present study, we have established β

Indexed as

Bacterial Proteinsbeta 2-MicroglobulinBiofilmsEscherichia coliAnimalsHumansBacterial Proteinsbeta 2-MicroglobulinCrl protein, Bacteriaamyloidantibiotic resistancebiofilmcurliβ2-microglobulin

Identifiers

PMID41706891
PMCPMC12933144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.