Evidence map›Paper›PMID 41706861›Full record

ArticleScience advances2026

Disrupted energy metabolism is associated with retinal ganglion cell degeneration in autosomal dominant optic atrophy.

Eugene Yu-Chuan Kang, Yun-Ju Tseng, Wei-Hao Peng, Hui-Chuan Hung, Pei-Hsuan Lin, Katrina P Montales, Emmet Sherman, John Peregrin, Ethan Hunghsi Wang, Chunya Kang and 15 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Eugene Yu-Chuan KangDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-6814-6530
Yun-Ju TsengDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wei-Hao PengSchool of Medicine, National Tsing Hua University, Hsinchu 300, Taiwan.ORCID 0000-0002-7524-1218
Hui-Chuan HungDepartment of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Pei-Hsuan LinDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Katrina P MontalesDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0009-0001-4260-2902
Emmet ShermanNanoscience Initiative at Advanced Science Research Center, Graduate Center of the City University of New York, New York, NY 10031, USA.
John PeregrinDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-6174-7026
Ethan Hunghsi WangDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Chunya KangDepartment of Education, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan.ORCID 0009-0000-9814-8369
Yu-Chuan TengGenomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Chen-Yang HuangSchool of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-6767-0389
Chia-Lung TsaiGenomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Ian Yi-Feng ChangGenomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.ORCID 0000-0001-5840-2051
Jiazhang ChenAdvanced Science Research Center (ASRC), Graduate Center of the City University of New York, New York, NY 10031, USA.ORCID 0000-0003-0632-7066
Gülgün TezelDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-7153-979X
Ye HeAdvanced Science Research Center (ASRC), Graduate Center of the City University of New York, New York, NY 10031, USA.ORCID 0000-0002-3936-4958
Tai-De LiNanoscience Initiative at Advanced Science Research Center, Graduate Center of the City University of New York, New York, NY 10031, USA.ORCID 0000-0003-0515-5135
Linsey StilesDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-1514-458X
Orian ShirihaiDivision of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8466-3431
Stephen H TsangDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-9082-2427
Chi-Chun LaiSchool of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Chi-Neu TsaiGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-5940-0696
Chyuan-Sheng LinDepartment of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.ORCID 0000-0002-6318-3743
Nan-Kai WangDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-6277-9879

Funding

Reprogramming the metabolome to overcome the genetic heterogeneity in retinitis pigmentosaR01EY031354 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, NAN-KAI · 2020 to 2024
$2.0M
High-End Biological Atomic Force MicroscopeS10OD030401 · OD · ADVANCED SCIENCE RESEARCH CENTER · PI LI, TAI-DE · 2022 to 2022
$1.3M
NEI NIH HHS R01 EY031354NIH HHS S10 OD030401
6 · The paper itself

Abstract

Autosomal dominant optic atrophy (ADOA) is a hereditary optic neuropathy caused by

Indexed as

Energy MetabolismOptic Atrophy, Autosomal DominantRetinal DegenerationRetinal Ganglion CellsAnimalsDisease Models, AnimalGlycolysisGTP PhosphohydrolasesHumansMiceMitochondriaOxidative StressGTP PhosphohydrolasesOpa1 protein, mouse

Identifiers

PMID41706861
PMCPMC12915623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.