Observational studyPloS one2026
Longitudinal brain atrophy and mortality among people living in homelessness and precarious housing: A brief report of a longitudinal study.
Observational study in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeople living in homelessness or precarious housing experience more health challenges and earlier mortality than the general population. We characterized longitudinal changes in magnetic resonance imaging (MRI) measures of brain atrophy among people living without stable housing, evaluated risk factors associated with longitudinal atrophy, and assessed whether atrophy was associated with mortality.
methodsData was collected as part of an ongoing longitudinal observational study of people living without stable housing in Vancouver, Canada. We included 307 participants with two-or-more brain MRI scans over an average of 7.0 years. We evaluated select risk factors for brain atrophy and assessed whether brain atrophy was associated with mortality during the study.
resultsAcross 307 participants and 1,173 brain MRI scans, alcohol dependence (β = -0.053, 95% confidence interval [CI] -0.075 to -0.032, p < 0.0001) and higher cardiovascular risk scores (β = -0.021, 95% CI -0.029 to -0.012, p < 0.0001) were associated with more rapid brain atrophy over time, and history of moderate or severe traumatic brain injury was associated with more atrophy at baseline (β = -0.27, 95% CI -0.46 to -0.075, p = 0.0075). More brain atrophy at baseline was associated with mortality during the study, adjusting for age, sex, and other comorbidities (Hazard Ratio [HR]Quartile1 = reference; HRQ2 = 2.37, p = 0.035; HRQ3 = 4.01, p = 0.00032; HRQ4 = 4.91, p < 0.0001). CONCLUSIONS AND RELEVANCE: Alcohol dependence, cardiovascular risk, and traumatic brain injury may represent particularly important risk factors for brain atrophy, and brain atrophy is associated with mortality among people living without stable housing. Targeting these modifiable risk factors may improve brain health and functioning outcomes among people living without stable housing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.