Evidence map›Paper›PMID 41706566›Full record

ArticleACS chemical neuroscience2026

Rewiring Receptor Activation: Mechanistic Insights into Toggle Switch Modulation by 25CN-NBx Compounds.

Vito F Palmisano, Micaela Vidal Sánchez, Juan J Nogueira

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vito F PalmisanoDepartment of Chemistry, Universidad Autonoma de Madrid, 28049 Madrid, Spain.
Micaela Vidal SánchezDepartment of Chemistry, Universidad Autonoma de Madrid, 28049 Madrid, Spain.
Juan J NogueiraDepartment of Chemistry, Universidad Autonoma de Madrid, 28049 Madrid, Spain.ORCID 0000-0001-7419-5670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of new treatments for neuropsychiatric disorders relies on a deeper understanding of the molecular mechanisms behind psychedelic compounds, particularly how they differentiate between hallucinogenic and antidepressant effects. In this study, we explore by molecular dynamics simulations a series of 25CN-NBx compounds bound to the 5-HT

Indexed as

HallucinogensReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor AgonistsHumansMolecular Dynamics SimulationHallucinogensReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor Agonists25CN-NBx compounds5-hydroxytryptamine 2A receptor (5-HT2AR)G protein-coupled receptor (GPCR)N-benzylvan der Waals (vdw)

Identifiers

PMID41706566
PMCPMC12964406

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.