ArticleJournal of clinical hypertension (Greenwich, Conn.)2026
Optimal Cut-Off Values of the Aldosterone-Renin Ratio in Different Age Groups for Primary Aldosteronism Screening.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Assessment of markers of primary aldosteronism in systemic sclerosis and their relationships with renal and cardiovascular outcomes.RMD open · 2026Article
- Effect of a Prior Two-Hour Postural Test on Seated Saline Suppression Test Results in Patients Predominantly Evaluated for Adrenal Incidentalomas.Journal of clinical medicine · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
This study sought to establish age-specific optimal cut-off values for the aldosterone-to-renin ratio (ARR) in screening for primary aldosteronism (PA). The analysis included 281 patients with confirmed PA and 1242 with essential hypertension (EH), categorized into four age groups: ≤39, 40-49, 50-59, and ≥60 years. A positive correlation was observed between ARR and age in both patient groups. Receiver operating characteristic analysis determined the optimal ARR cut-offs to be 2.3, 2.8, 3.1, and 3.6 for the respective age groups, with all demonstrating high diagnostic accuracy. Further evaluation revealed that for patients under 50-years-old, a unified ARR cut-off of 2.4 provided high sensitivity and specificity, while for patients aged 50 or older, a cut-off of 3.7 was more appropriate. In conclusion, the optimal ARR cut-off for PA screening increases with age, and we recommend using a value of 2.4 for patients under 50 and 3.7 for those aged 50 or older to achieve superior diagnostic performance.
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