Evidence map›Paper›PMID 41706385›Full record

ArticleThe international journal of cardiovascular imaging2026

Utility of stress parameters to determine prognosis following normal exercise SPECT myocardial perfusion imaging.

Zeinab Shirazi, Zohreh Adinehpour, Toby David Small, R Glenn Wells, Kevin E Boczar, Benjamin J W Chow, Gary R Small

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zeinab ShiraziDivision of Nuclear Medicine and Molecular Imaging Department of Medicine, University of Ottawa, Ottawa, Canada.
Zohreh AdinehpourDivision of Nuclear Medicine and Molecular Imaging Department of Medicine, University of Ottawa, Ottawa, Canada.
Toby David SmallDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
R Glenn WellsDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Kevin E BoczarDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Benjamin J W ChowDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
Gary R SmallDivision of Cardiology, Department of Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. gsmall@ottawaheart.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise parameters achieved during an exercise stress myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) study may help to predict clinical outcomes. The aim of our study was to compare different exercise stress parameters to determine their prognostic utility following a normal rest- exercise stress MPI.

methodsWe performed a retrospective cohort study on 3290 consecutive patients who had undergone rest-exercise-stress MPI from 2017 to 2024. 1020 patients had normal perfusion images and were included in the analysis. The primary endpoint of the study was a composite of all-cause mortality, non-fatal myocardial infarction and coronary revascularization. Using multivariable survival analysis, we evaluated the incremental prognostic risks of exercise and clinical factors to predict the primary end point.

results58% of the cohort were male, the mean age was 59 ± 10 years. During a follow-up of 55 ± 22 months, 44 primary events occurred. On univariable and multivariable survival analysis achieving < 85% of the maximum age predicted heart rate (APHR

conclusionsRPP

Indexed as

Coronary Artery DiseaseCoronary CirculationExercise TestMyocardial Perfusion ImagingTomography, Emission-Computed, Single-PhotonAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsCoronary artery diseaseExercise stress MPIExercise test parametersRate pressure productRisk stratification

Identifiers

PMID41706385
PMCPMC13253776

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.