ArticleMedical oncology (Northwood, London, England)2026
Bio-mediated synthesis of zinc oxide nanoparticles from Crossandra infundibuliformis leaves: A potent inducer of apoptosis in lung cancer cells.
Article in Medical oncology (Northwood, London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Zinc oxide nanoparticles (ZnO-NPs) have gained attention as potential anticancer agents due to their selective cytotoxicity and ability to induce apoptosis. In this study, we evaluated the anticancer efficacy and apoptotic mechanism of biosynthesised ZnO nanoparticles prepared using the aqueous leaf extract of Crossandra infundibuliformis (CI-ZnO-NPs) in human lung adenocarcinoma (A549) cells. The synthesised CI-ZnO-NPs exhibited a characteristic UV-Visible absorbance peak at 277 nm. while FT-IR analysis confirmed the involvement of phytochemical functional groups in nanoparticle formation and stabilisation. XRD analysis revealed the crystalline nature of CI-ZnO-NPs, while SEM and TEM images depicted the semi-spherical agglomerated nanoparticles with an average grain size of 37.26 ± 0.92 nm. The surface charge was measured at -25 mV with the hydrodynamic particle size of 248.7 nm. The anti-cancer activity of CI-ZnO-NPs, evaluated through the MTT assay, showed a concentration-dependent response, with an IC
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