ArticleEcotoxicology (London, England)2026
Efficacy of lufenuron on Allium cepa: cytogenotoxic, molecular and in silico docking studies.
Article in Ecotoxicology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multi-level evaluation of zinc sulfate toxicity and its modulation by Helichrysum arenarium in Allium cepa.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lufenuron, a benzoylurea insecticide that inhibits chitin synthesis, was evaluated for its cytogenotoxic and DNA-damaging effects on Allium cepa root meristem cells using root growth inhibition, Allium anaphase-telophase, comet, RAPD-PCR, and flow cytometry assays. Molecular docking was also performed to investigate the interactions of lufenuron with cytochrome P450 enzymes (CYP81A12 and CYP81A21) and a standard B-form double-stranded DNA dodecamer model (12 base pairs). Root growth significantly decreased from 3.87 ± 0.44 cm at low doses to 0.26 ± 0.12 cm at high concentrations according to the root growth inhibition test. Lufenuron exposure caused dose- and time-dependent reductions in mitotic index (MI) and increases in chromosomal aberrations (CAs) in anaphase-telophase cells such as disturbed anaphase-telophase, chromosomal laggards, stickiness, anaphase bridges) and other cells (micronuclues and c-metaphase) along with DNA damage. The results of flow cytometry demonstrated the existence of subG1 arrest-induced early apoptosis. Compared with the negative control, lufenuron-treated roots exhibited distinct RAPD polymorphisms characterized by the loss and/or emergence of specific DNA bands. Numerical and phenetic analyses of RAPD profiles clearly demonstrated a dose- and time-dependent genotoxic response to lufenuron exposure. Molecular docking studies showed that lufenuron binds strongly to CYP81A12, CYP81A21, and DNA with greater affinity than the positive control (MMS), fitting into enzyme active sites and the DNA minor groove with an intercalation gap. Overall, the study demonstrates that lufenuron exerts notable cytogenotoxic and DNA-damaging effects on A. cepa roots. Therefore, its agricultural use should be carefully regulated to minimize potential risks to non-target organisms and environmental health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.