The Impact of REM Sleep Deprivation on ER Stress and Alzheimer-Like Pathology: Therapeutic Potential of Melatonin.

A Çakır, S Şehzade, C Koç, S Çilingir, D Acar, G Süyen, A Bican Demir, N Kahveci

Abstract read

In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A ÇakırFaculty of Medicine, Department of Physiology, Bursa Uludağ University, University Street, Bursa, 16059, Turkey.ORCID http://orcid.org/0000-0001-7729-7373

S ŞehzadeFaculty of Medicine, Department of Physiology, Bursa Uludağ University, University Street, Bursa, 16059, Turkey.ORCID http://orcid.org/0000-0003-2452-790X

C KoçExperimental Animal Breeding and Research Unit (DENHAB), Bursa Uludağ University, University Street, Bursa, 16059, Turkey.ORCID http://orcid.org/0000-0002-6097-5585

S ÇilingirAcıbadem University Technology Transfer Office, Kayışdağı Avenue, Istanbul, 34638, Turkey.ORCID http://orcid.org/0000-0002-0506-2871

D AcarGraduate School of Health Sciences, Department of Physiology, Acıbadem University, Kayışdağı Avenue, Istanbul, 34638, Turkey.ORCID http://orcid.org/0000-0003-2900-2969

G SüyenGraduate School of Health Sciences, Department of Physiology, Acıbadem University, Kayışdağı Avenue, Istanbul, 34638, Turkey.ORCID http://orcid.org/0000-0003-0863-1547

A Bican DemirFaculty of Medicine, Department of Neurology, Bursa Uludağ University, University Street, Bursa, 16059, Turkey.ORCID http://orcid.org/0000-0001-6739-8605

N KahveciFaculty of Medicine, Department of Physiology, Bursa Uludağ University, University Street, Bursa, 16059, Turkey. nevka@uludag.edu.tr.ORCID http://orcid.org/0000-0003-0841-8201

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

REM sleep deprivation (REMSD) contributes to neurodegenerative diseases like Alzheimer’s Disease (AD). This study examined REMSD’s effects on cognition, ER stress, and AD-like pathology in rats, alongside melatonin’s therapeutic potential. REMSD was induced for six days using the modified multiple platform method (MMPM). Cognitive function was tested via the Morris Water Maze (MWM). Rats received melatonin (20 mg/kg), 4-PBA (as a positive control, 100 mg/kg), or vehicle during deprivation/recovery periods. Western blotting and ELISA assessed ER stress markers (BiP, pIRE1, pPERK, peIF2-α, CHOP and GRP94, GADD34), Alzheimer related molecules (Aβ40/42, Tau, APP, GSK3β) and apoptosis-related proteins (Caspase 2, Caspase 12, BAX/Bcl-2). In addition, the mRNA expression levels of ATF4 and ATF6 were determined by PCR. Recovery sleep restored cognition, but melatonin/4-PBA enhanced it further. REMSD was associated with increased ER stress and AD-like pathology, whereas melatonin and 4-PBA appeared to attenuate these alterations, possibly by influencing the unfolded protein response (UPR) and reducing protein misfolding. Melatonin shows promise in countering SD-associated neurodegeneration, highlighting sleep’s role in proteostasis and its potential clinical use in AD and protein-misfolding disorders.

Indexed as

Alzheimer DiseaseEndoplasmic Reticulum StressMelatoninSleep DeprivationSleep, REMAnimalsButylaminesMaleRats4-phenylbutylamineButylaminesMelatonin4-PBAAlzheimer’s diseaseEndoplasmic reticulum stressMelatoninSleep deprivationUnfolded protein response

Identifiers

PMID41706263

DOI10.1007/s11064-026-04696-9

PMCPMC12916959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.