Evidence map›Paper›PMID 41706222›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Midbrain length by the one-line method predicts motor outcome after deep brain stimulation in Parkinson's disease.

Hikaru Kamo, Wataru Sako, Genko Oyama, Akimitsu Suda, Masanobu Ito, Hirokazu Iwamuro, Atsushi Umemura, Taku Hatano, Koji Kamagata, Shigeki Aoki and 1 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Hikaru KamoDepartment of Neurology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Tokyo, 113-8421, Bunkyo-ku, Japan.ORCID http://orcid.org/0000-0002-9408-7893
Wataru SakoDepartment of Neurology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Tokyo, 113-8421, Bunkyo-ku, Japan. w.sako.fn@juntendo.ac.jp.ORCID http://orcid.org/0000-0003-2009-2486
Genko OyamaDepartment of Neurology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Tokyo, 113-8421, Bunkyo-ku, Japan. g_oyama@juntendo.ac.jp.
Akimitsu SudaDepartment of Neurology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Tokyo, 113-8421, Bunkyo-ku, Japan.
Masanobu ItoDepartment of Psychiatry, Juntendo, University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Hirokazu IwamuroDepartment of Neurosurgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Atsushi UmemuraDepartment of Neurosurgery, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Taku HatanoDepartment of Neurology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Tokyo, 113-8421, Bunkyo-ku, Japan.ORCID http://orcid.org/0000-0002-6808-0444
Koji KamagataDepartment of Radiology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Shigeki AokiDepartment of Radiology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Tokyo, 113-8421, Bunkyo-ku, Japan.

Funding

Kaken Pharmaceutical 23K11880Kaken Pharmaceutical 23K19409
6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease (PD). The outcome of DBS varies from patient to patient.

objectivesWe investigated the preoperative changes in the midbrain to predict DBS outcomes.

methodsPatients with PD who underwent bilateral STN-DBS at Juntendo University Hospital between June 2019 and October 2020 were included. We compared the Movement Disorders Society Unified Parkinson's Disease Rating Scale Part III score in the off state 3 months before and 1 year after surgery, and the difference in the score was defined as the motor outcome after DBS. Preoperative magnetic resonance images of the midbrain were evaluated using FreeSurfer and the One-Line Method.

resultsA total of 34 patients were enrolled. Multiple regression analysis with least squares indicated that the volume of the midbrain measured using FreeSurfer had no significance as an independent variable (p = 0.16), whereas the midbrain length evaluated using the One-Line Method had significance (p < 0.05) when the outcome of motor symptoms was set as the dependent variable.

conclusionsWe showed that midbrain size evaluated using the One-Line Method was a good predictor of the motor outcome after STN-DBS, but volume measured using FreeSurfer was not. The One-Line Method was considered to detect changes in size specifically in the midbrain tegmentum, which is associated with PD motor symptoms. Thus, we present a simple and useful method for predicting poor outcomes after STN-DBS treatment in patients with PD with disease progression.

Indexed as

Deep Brain StimulationMesencephalonParkinson DiseaseAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesSubthalamic NucleusTreatment OutcomeDeep brain stimulationDigital biomarkerParkinson’s diseasePrognostic factor

Identifiers

PMID41706222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.