Evidence map›Paper›PMID 41706109›Full record

ArticlePediatric cardiology2026

Tricuspid Regurgitation and Impact of Surgical Valve Intervention in the Single Ventricle Reconstruction Trial.

J F Cnota, S M Chowdhury, A Floh, R Gongwer, B H Goot, J P Jacobs, M A Jolley, S Kirmani, D J LaPar, J C Levine and 10 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00115934 (Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00115934 nacompletednot on this map

Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction (A Trial Conducted by the Pediatric Heart Network)

TypeinterventionalSponsorCarelon ResearchRan2005 to 2009Enrolled555ConditionsHeart Defects, CongenitalArmsBlalock-Taussig pulmonary artery shunt, Right ventricular to pulmonary artery shunt
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

J F CnotaDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Heart Institute, 3333 Burnet Avenue, Cincinnati, OH, 45244, USA. James.cnota@cchmc.org.
S M ChowdhuryDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
A FlohDepartment of Pediatrics and Labatt Family Heart Centre, Hospital for Sick Children, University of Toronto, Toronto, Canada.
R GongwerNew England Research Institutes, Watertown, MA, USA.
B H GootDepartment of Pediatrics, Herma Heart Institute, Children's Wisconsin and Medical College of Wisconsin, Milwaukee, WI, USA.
J P JacobsDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Florida, Gainesville, FL, USA.
M A JolleyDivision of Pediatric Cardiology, Department of Anesthesia and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
S KirmaniDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
D J LaParMorgan Stanley Children's Hospital of New York Presbyterian Columbia University Medical Center and Department of Pediatrics, Division of Cardiology Columbia University, New York, NY, USA.
J C LevineDepartment of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA, USA.
A B LewisDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
R H PignatelliPediatric Cardiology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.
C PizarroAlfred I. DuPont Hospital for Children and Department of Pediatrics, Division of Cardiology Thomas Jefferson University, Wilmington, DE, USA.
T C SlesnickDepartment of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, USA.
T ThorssonDepartment of Pediatrics, Medical School, University of Michigan and Michigan Medicine, Ann Arbor, MI, USA.
F TrachtenbergNew England Research Institutes, Watertown, MA, USA.
D T TruongDepartment of Pediatrics, University of Utah and Primary Children's Hospital, Salt Lake City, UT, USA.
J W NewburgerNew England Research Institutes, Watertown, MA, USA.
P C FrommeltDepartment of Pediatrics, Herma Heart Institute, Children's Wisconsin and Medical College of Wisconsin, Milwaukee, WI, USA.
Pediatric Heart Network Investigators

Funding

NHLBI NIH HHS HL135680, HL135685, HL135683, HL135689, HL135646, HL135665, HL135678, HL135682, HL135666, HL135691, HL068270
6 · The paper itself

Abstract

Tricuspid regurgitation (TR) is common in single right ventricle (RV) anomalies and affects outcomes during staged surgical palliations. The Pediatric Heart Network's (PHN) Single Ventricle Reconstruction trial followed children with single RV to age 6 years. This study compared serial echocardiographic measures of TR during staged palliations and determine the impact of TR and tricuspid valve (TV) intervention on transplant-free survival in the PHN cohort. Study echocardiograms were performed at 6 pre-determined times: baseline, post-Norwood, pre-stage II, age 14 months, pre-Fontan, and age 6 years. TR was categorized as ≤ mild or > mild. McNemar's test compared TR across time; t-tests compared RV size/function by TR category; and survival analysis assessed the effect of > mild TR on transplant-free survival. TR was assessed in 543 participants prior to Norwood. From baseline to post-Norwood, those with > mild TR increased from 12 to 24% (p < 0.001). Thereafter, the proportion of surviving participants with > mild TR was stable. Participants with > mild TR had increased baseline TV annular area, and increased RV volume but not decreased function. Transplant-free survival at 6 years was lower with > mild TR at any time except pre-Fontan. 78 TV interventions occurred in 66 participants. Those with TV intervention at the Norwood and/or Stage II had a higher rate of death/transplant than those without or those who had a later intervention. At baseline, post Norwood and pre-stage II, > mild TR is associated with decreased transplant-free survival. TV intervention at the Norwood or Stage II operations was not associated with improved survival.Clinical Trial Registration: NCT00115934.

Indexed as

Hypoplastic left heart syndromeNorwood procedureSurvivalTricuspid regurgitation

Identifiers

PMID41706109

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.