Evidence map›Paper›PMID 41705942›Full record

ArticleMolecular biology of the cell2026

Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex.

Gregory J Schwarz, Joanna R Suber, Devika Andhare, Michael J Ragusa, Jennifer Landino

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Distinct impact of PI(4)P flux on PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Gregory J SchwarzDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover NH 03755.
Joanna R SuberDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover NH 03755.
Devika AndhareDepartment of Chemistry, Dartmouth College, Hanover NH 03755.
Michael J RagusaDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover NH 03755.ORCID 0000-0002-0231-0876
Jennifer LandinoDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover NH 03755.ORCID 0000-0002-2755-9029

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Dissecting the Molecular Mechanisms of Selective AutophagyR35GM128663 · NIGMS · DARTMOUTH COLLEGE · PI Michael Joseph Ragusa · 2018 to 2026
$3.5M
Investigating the mechanism of self-organized cortical patterning in an artificial cortexR00GM147826 · NIGMS · DARTMOUTH COLLEGE · PI LANDINO, JENNIFER ELAINE · 2023 to 2025
$747k
Investigating the mechanism of self-organized cortical patterning in an artificial cortexK99GM147826 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANDINO, JENNIFER ELAINE · 2022 to 2023
$105k
NIGMS NIH HHS K99 GM147826NIGMS NIH HHS P20 GM113132NIGMS NIH HHS R00 GM147826NIGMS NIH HHS R35 GM128663
6 · The paper itself

Abstract

Cortical excitability, a phenomenon in which the cell cortex is dynamically patterned with waves of F-actin assembly, has been described in a variety of model systems, including embryos of mammals, flies, frogs, and echinoderms, as well as a variety of cultured cells. While the cortical F-actin network is closely linked with the plasma membrane, it is not known if membrane composition or fluidity regulates dynamic cytokinetic patterning. Phospholipids partition within the plasma membrane during cytokinesis and phosphoinositides play a key regulatory role in other excitable systems, suggesting a role for membrane-dependent regulation of cytokinetic patterning. Here, we use an artificial cell cortex comprised of

Indexed as

ActinsCell Membranerho GTP-Binding ProteinsAnimalsCholesterolCytokinesisLipid BilayersPhosphatidylethanolaminesPhosphatidylinositol 4,5-DiphosphatePhospholipidsSphingomyelinsXenopus laevisActinsCholesterolLipid BilayersPhosphatidylethanolaminesPhosphatidylinositol 4,5-DiphosphatePhospholipidsrho GTP-Binding ProteinsSphingomyelins

Identifiers

PMID41705942
PMCPMC13008262

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.