Evidence map›Paper›PMID 41705904›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026

SGK1 signaling: an important modulator of CFTR function and early immune response in mouse intestine.

Caroline Muiler, Anderson Santos, Nadia A Ameen

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Caroline MuilerDepartment of Pediatrics/Gastroenterology and Hepatology, Yale School of Medicine, New Haven, Connecticut, United States.ORCID 0000-0002-4824-5555
Anderson SantosDepartment of Pediatrics/Gastroenterology and Hepatology, Yale School of Medicine, New Haven, Connecticut, United States.ORCID 0000-0002-6185-3491
Nadia A AmeenDepartment of Pediatrics/Gastroenterology and Hepatology, Yale School of Medicine, New Haven, Connecticut, United States.ORCID 0000-0002-9619-4932

Funding

Glucocorticoid and SGK1 regulation of CFTR in the intestine: role in diarrheaR01DK077065 · NIDDK · YALE UNIVERSITY · PI AMEEN, NADIA A. · 2008 to 2024
$5.8M
Glucocorticoid and SGK1 Regulation of CFTR in the Intestine: Role in DiarrheaR56DK077065 · NIDDK · YALE UNIVERSITY · PI AMEEN, NADIA A. · 2020 to 2020
$418k
HHS | National Institutes of Health (NIH) R01DK077065NIDDK NIH HHS R01 DK077065NIDDK NIH HHS R56 DK077065
6 · The paper itself

Abstract

Glucocorticoid (GC) and stress-induced serum- and glucocorticoid-inducible kinase 1 (SGK1) signaling rapidly modulate intestinal epithelial transport, yet whether epithelial SGK1 is required to couple GC signaling to functional cystic fibrosis transmembrane conductance regulator (CFTR) output in vivo has remained unclear. We examined this question using

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorImmediate-Early ProteinsIntestinal MucosaProtein Serine-Threonine KinasesAnimalsDexamethasoneGlucocorticoidsMaleMiceMice, Inbred C57BLMice, KnockoutSerum-Glucocorticoid Regulated KinasesSignal TransductionCftr protein, mouseCystic Fibrosis Transmembrane Conductance RegulatorDexamethasoneGlucocorticoidsImmediate-Early ProteinsProtein Serine-Threonine KinasesSerum-Glucocorticoid Regulated KinasesCFTRdexamethasoneinflammationintestineSGK1

Identifiers

PMID41705904
PMCPMC13267886

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.