Evidence map›Paper›PMID 41705839›Full record

ArticleJournal of virology2026

Dissecting the steps in early simian immunodeficiency virus dissemination following mucosal and intravenous infection of rhesus macaques.

Steffen S Docken, Agatha Macairan, Timothy E Schlub, Christine M Fennessey, Benjamin Varco-Merth, Louis J Picker, Afam A Okoye, Taina T Immonen, Deborah Cromer, Brandon F Keele and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Steffen S DockenKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-3771-5504
Agatha MacairanAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.ORCID 0009-0002-4847-9631
Timothy E SchlubSydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-7746-9649
Christine M FennesseyAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.ORCID 0000-0002-8736-8523
Benjamin Varco-MerthVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Louis J PickerVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0003-0546-398X
Afam A OkoyeVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0001-9671-550X
Taina T ImmonenAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.ORCID 0000-0003-4521-0696
Deborah CromerKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-5276-5094
Brandon F KeeleAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.ORCID 0000-0002-2381-1151
Miles P DavenportKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NCI NIH HHS 75N91019D00024NIH HHS 75N91019D00024NIH HHS P51 OD011092
6 · The paper itself

Abstract

Early HIV infection involves the transmission of a small number of virions and the subsequent expansion and spread of the virus. The early phases of infection represent an important opportunity for viral control, although relatively little is understood about the determinants of the rate of spread or the "bottlenecks" the virus must negotiate during this time. Here, we use the barcoded simian immunodeficiency virus (SIV) infection model to analyze the kinetics of early SIV infection

Indexed as

Simian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusVirus ReplicationAnimalsDisease Models, AnimalFemaleMacaca mulattaMucous MembraneViral Loadbarcoded virusearly infection eventsHIVsimian immunodeficiency virusviral dissemination

Identifiers

PMID41705839
PMCPMC13011353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.