Evidence map›Paper›PMID 41705833›Full record

ArticleMicrobiology spectrum2026

Bacterial microbiome analysis of vaginal, cervical, and endometrial samples in patients with adenomyosis during the window of implantation.

Nika Troha, Tomaž M Zorec, Lea Hošnjak, Katja Strašek Smrdel, Andraž Celar Šturm, Vesna Šalamun, Snježana Grazio Frković, Eda Vrtačnik Bokal, Mario Poljak

Abstract read
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In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nika TrohaFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-5421-5726
Tomaž M ZorecFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0001-8191-0994
Lea HošnjakInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Katja Strašek SmrdelFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Andraž Celar ŠturmInstitute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Vesna ŠalamunFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Snježana Grazio FrkovićFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Eda Vrtačnik BokalFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Mario PoljakFaculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.ORCID 0000-0002-3216-7564

Funding

Javna Agencija za Raziskovalno Dejavnost RS P3-0083
6 · The paper itself

Abstract

Adenomyosis is a chronic gynecological condition affecting a substantial portion of women of reproductive age. With symptoms including abnormal uterine bleeding, chronic pelvic pain (CPP), dysmenorrhea, and infertility, poor response to symptomatic treatment and unfavorable outcomes of assisted reproductive technologies, it remains a significant diagnostic and therapeutic challenge. Here, we analyzed microbial compositions of the reproductive tract of women with adenomyosis ( IMPORTANCE: Adenomyosis poorly responds to treatment and assisted reproductive technologies. Here, we report a comprehensive 16S rRNA-based analysis of vaginal, cervical, and endometrial samples, obtained minimally invasively (transcervically) in a cohort of Caucasian women during the receptive phase of endometrium. Results revealed the least invasive option, vaginal microbiome sampling, reliably predicts the microbiome compositions of cervix and endometrium. We showed substantial variation in microbial composition of adenomyosis patients.

Indexed as

AdenomyosisBacteriaCervix UteriEndometriumMicrobiotaVaginaAdultEmbryo ImplantationFemaleGardnerella vaginalisHumansLactobacillusLactobacillus gasseriRNA, Ribosomal, 16SYoung AdultRNA, Ribosomal, 16SadenomyosisGardnerella vaginalisinfertilityLactobacillus gasseriLactobacillus inersmicrobiomereproductive healthreproductive tractwindow of implantation

Identifiers

PMID41705833
PMCPMC13055214

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.