Evidence map›Paper›PMID 41705703›Full record

ArticleThe American journal of gastroenterology2026

Steatotic Liver Disease has Surpassed Viral Hepatitis as the Leading Cause of Cirrhosis in the US Veterans Health System.

Pedro Ochoa-Allemant, Akshatha Kiran, Catherine Mezzacappa, David E Kaplan, Nadim Mahmud

Abstract read
In one paragraph

Article in The American journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pedro Ochoa-AllemantDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7826-655
Akshatha KiranDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7131-9727
Catherine MezzacappaSection of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-7181-6902
David E KaplanDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3839-336
Nadim MahmudDepartment of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1889-3954

Funding

CLINICAL EPIDEMIOLOGY TRAINING IN GASTROENTEROLOGYT32DK007740 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI James D Lewis · 1997 to 2026
$9.2M
Impact of mammalian target of rapamycin inhibitor therapy on aging-related outcomesR01AG079911 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David E Kaplan, DOUGLAS EARL SCHAUBEL · 2023 to 2026
$1.6M
The role of immunosuppression and environmental exposures on incident and subsequent keratinocyte carcinoma risk after solid organ transplantR01CA292523 · NCI · UNIVERSITY OF PENNSYLVANIA · PI David Seth Goldberg, David E Kaplan · 2025 to 2026
$968k
Improving Surgical Risk Prediction and Decision Making among Patients with CirrhosisK08DK124577 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MAHMUD, NADIM · 2021 to 2025
$835k
Understanding Patient Preferences for Surgical Management in the Setting of Cirrhosis: A Mixed-Methods ApproachR03DK134794 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MAHMUD, NADIM · 2024 to 2025
$244k
CSRD VA I01 CX002010NCI NIH HHS R01 CA292523NIA NIH HHS R01 AG079911NIDDK NIH HHS K08 DK124577NIDDK NIH HHS R03 DK134794NIDDK NIH HHS T32 DK007740NIH HHS K08DK124577NIH HHS R01-AG079911NIH HHS R01-CA292523NIH HHS R03-DK134794NIH HHS T32DK007740-28U.S. Department of Veterans Affairs CSP 2023U.S. Department of Veterans Affairs Merit I01-CX002010U.S. Department of Veterans Affairs Merit I01-CX002147
6 · The paper itself

Abstract

introductionContemporary population-level estimates of the burden of cirrhosis using the revised steatotic liver disease (SLD) nomenclature are lacking.

methodsRetrospective cohort study of patients with incident cirrhosis from 2008 to 2023 within the Veterans Health Administration.

resultsMetabolic dysfunction-associated steatotic liver disease (MASLD) has become the leading contributor to cirrhosis incidence and prevalence. Although hepatitis C virus cirrhosis has declined, it remains highly prevalent. Incident MASLD cases are balanced by deaths, whereas incident metabolic and alcohol-associated liver disease and alcohol-associated liver disease cases exceeded deaths. DISCUSSION: Substantial epidemiologic shifts in cirrhosis in the United States over the past decade, driven by the rising burden of SLD, underscore the need for multidisciplinary strategies targeting metabolic risk factors and alcohol use.

Indexed as

Fatty LiverHepatitis, Viral, HumanLiver CirrhosisAgedFemaleHumansIncidenceMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsUnited StatesVeterans HealthALDcirrhosisMASLDMetALDprevalencesteatotic liver disease

Identifiers

PMID41705703
PMCPMC13110510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.