Evidence map›Paper›PMID 41705663›Full record

ArticleeLife2026

Impaired excitability of fast-spiking neurons in a novel mouse model of

Eric R Wengert, Sophie R Liebergall, Teresa Jimenez, Melody A Cheng, Kelly H Markwalter, Jerome Clatot, Yerahm Hong, Leroy Arias, Eric D Marsh, Xiaohong Zhang and 4 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Eric R WengertDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID https://orcid.org/0000-0001-7679-4183
Sophie R LiebergallDepartment of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Teresa JimenezThe Center for Brain Research in Development, Genetics, and Engineering (BRIDGE), Philadelphia, United States.
Melody A ChengSchool of Arts and Sciences, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Kelly H MarkwalterDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID https://orcid.org/0000-0002-6879-4228
Jerome ClatotDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Yerahm HongSchool of Engineering and Applied Sciences, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Leroy AriasSchool of Arts and Sciences, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Eric D MarshDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Xiaohong ZhangDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Theodoros TsetsenisDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Ala SomarowthuDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Naiara AkizuThe Center for Brain Research in Development, Genetics, and Engineering (BRIDGE), Philadelphia, United States.ORCID https://orcid.org/0000-0001-9222-6960
Ethan M GoldbergDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID https://orcid.org/0000-0002-7404-735X

Funding

Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Mechanistically-oriented therapy for a progressive myoclonus epilepsyR01NS122887 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2022 to 2026
$2.5M
Mechanisms of cellular, synaptic and circuit dysfunction in Kcnc1-related epileptic encephalopathyF32NS126234 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WENGERT, ERIC RYAN · 2022 to 2024
$218k
Cellular and circuit function of Ndnf-expressing interneurons in a mouse model of a neurodevelopmental disorderF31NS132519 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LIEBERGALL, SOPHIE ROSE · 2023 to 2025
$124k
Holt Family Epilepsy Neurogenetics FellowshipNINDS NIH HHS F31NS132519NINDS NIH HHS F32NS126234NINDS NIH HHS R01NS122887NINDS NIH HHS T32 NS091006
6 · The paper itself

Abstract

The recurrent pathogenic variant

Indexed as

Action PotentialsEpilepsyNeuronsShaw Potassium ChannelsAnimalsDisease Models, AnimalInterneuronsMiceMice, TransgenicKcnc1 protein, mouseShaw Potassium ChannelsepilepsygeneticsgenomicsKCNC1Kv3.1mouseneurosciencepotassium channelsPV interneurontwo-photon calcium imaging

Identifiers

PMID41705663
PMCPMC12916103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.