Evidence map›Paper›PMID 41705594›Full record

ArticleThe journal of obstetrics and gynaecology research2026

Co-Occurrence of Osteogenesis Imperfecta Type III and Chronic Abruption-Oligohydramnios Sequence: A Case Report Suggesting a Possible Role of Type I Collagen Fragility.

Ayumi Okuyama, Tatsuya Izdebski, Minako Goto, Kohei Seo, Makiko Tominaga, Kiyotake Ichizuka

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of obstetrics and gynaecology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ayumi OkuyamaDepartment of Obstetrics and Gynecology, SHOWA Medical University, Northern Yokohama Hospital, Yokohama, Japan.
Tatsuya IzdebskiDepartment of Obstetrics and Gynecology, SHOWA Medical University, Northern Yokohama Hospital, Yokohama, Japan.
Minako GotoDepartment of Obstetrics and Gynecology, SHOWA Medical University, Northern Yokohama Hospital, Yokohama, Japan.
Kohei SeoDepartment of Obstetrics and Gynecology, SHOWA Medical University, Northern Yokohama Hospital, Yokohama, Japan.
Makiko TominagaClinical Genetics and Genomic Medicine Center, SHOWA Medical University, Northern Yokohama Hospital, Yokohama, Japan.
Kiyotake IchizukaDepartment of Obstetrics and Gynecology, SHOWA Medical University, Northern Yokohama Hospital, Yokohama, Japan.ORCID https://orcid.org/0000-0003-2436-4469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy complicated by severe osteogenesis imperfecta (OI) is rare, and chronic abruption-oligohydramnios sequence (CAOS) is an uncommon obstetric disorder characterized by persistent bleeding and oligohydramnios without membrane rupture. To our knowledge, this is the first report describing the coexistence of type III OI and CAOS. A 24-year-old woman with OI developed recurrent bleeding early in pregnancy. Genetic testing revealed a novel COL1A1 splice-site variant (c.1876-2A>C). Ultrasonography showed a circumferential subchorionic hematoma and progressive fluid loss, leading to CAOS diagnosis at 19 weeks. Despite amnioinfusion, the amniotic cavity collapsed, and pregnancy was terminated via cesarean section at 20 weeks. Placental pathology showed hemosiderin and fibrin deposition. In this case, both functional and structural factors possibly associated with type I collagen abnormalities may have contributed to CAOS development. Although causality cannot be proven, persistent bleeding in severe OI may warrant greater caution for progression to CAOS.

Indexed as

Collagen Type IOligohydramniosOsteogenesis ImperfectaCollagen Type I, alpha 1 ChainFemaleHumansPregnancyYoung AdultCOL1A1 protein, humanCollagen Type ICollagen Type I, alpha 1 Chaincase reportsCOL1A1oligohydramniososteogenesis imperfectauterine hemorrhage

Identifiers

PMID41705594
PMCPMC12914767

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.