ArticleACS nano2026
Collagenase-Functionalized Liposomes Overcome Stromal Barriers in Pancreatic Cancer.
Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Engineering Functional Biomaterials for Targeted and Localized Cancer Drug Delivery: A Structure-Property-Performance Design Perspective.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Desmoplasia and therapeutic resistance in pancreatic ductal adenocarcinoma.Cancer letters · 2026Review
- Review
- Tumor microenvironment-specific nanomedicine: from biology-driven to multi-omics-guided precision engineering.Journal of hematology & oncology · 2026Review
- Liposomal Nanoparticulate Drug Delivery Systems: Strategies to Destabilize Biological Membranes at the Target Tissue.International journal of nanomedicine · 2026Review
- Harnessing Nanocarriers to Improve Psychiatric Treatment: Progress, Limitations, and Future Directions.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) features a dense desmoplastic stroma dominated by type I collagen, which forms a physical barrier that limits vascular perfusion and drug penetration, resulting in poor therapeutic outcomes. Here, we report gemcitabine-loaded collagenase-conjugated liposomes (GLCLs) that enzymatically remodel the collagen-rich extracellular matrix (ECM) while delivering a cytotoxic payload. GLCL retained enzymatic activity and stability, exhibited prolonged circulation, and achieved superior tumor accumulation with deeper and more homogeneous intratumoral gemcitabine penetration than nonfunctionalized liposomes. In PDAC-bearing mice, GLCL showed a 6-fold higher tumor growth inhibition (69.8%) than gemcitabine-loaded liposomes without collagenase (GLL; 10.9%) at the same dose. Importantly, this work provides the first molecular-level validation of nanocarrier-mediated drug penetration in PDAC, achieved through a multiscale approach combining
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.