Evidence map›Paper›PMID 41705479›Full record

ArticleMolecular pharmaceutics2026

Investigating the Theranostic Potential of Elementally Matched [

Shelbie J Cingoranelli, Emily Putnam, Hailey A Houson, Grayson R Gimblet, Sharon Samuel, Volkan Tekin, Suzanne E Lapi

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Research square · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shelbie J CingoranelliDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.ORCID 0009-0002-5578-0342
Emily PutnamDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Hailey A HousonDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Grayson R GimbletDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.ORCID 0000-0002-1312-9714
Sharon SamuelDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Volkan TekinDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Suzanne E LapiDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.ORCID 0000-0003-0090-0191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The theranostic approach, which employs diagnostic radiopharmaceuticals to select patients who would benefit from targeted radiotherapy agents, has become an invaluable strategy for effective medical care. Scandium radionuclides offer the advantage of forming elementally matched and chemically identical diagnostic and therapeutic compounds, making them ideal candidates for this strategy. PSMA-617 is an established prostate-specific membrane antigen targeting agent and can be used as a proof of concept to investigate

methodsCellular uptake, competitive binding assays, and internalization studies were carried out using LNCaP or PC-3 cell lines. [

results

conclusionsTwo chemically identical, PSMA-targeting radioscandium pharmaceuticals demonstrated

Indexed as

DipeptidesHeterocyclic Compounds, 1-RingProstatic NeoplasmsRadioisotopesRadiopharmaceuticalsScandiumAnimalsCell Line, TumorHumansMaleMiceMice, NudePC-3 CellsPositron-Emission TomographyProstate-Specific AntigenTheranostic NanomedicineDipeptidesHeterocyclic Compounds, 1-RingProstate-Specific AntigenPSMA-617RadioisotopesRadiopharmaceuticalsScandiumPETPSMAradioscandiumSc-43Sc-47targeted radiotherapyTheranostics

Identifiers

PMID41705479
PMCPMC12958282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.