Evidence map›Paper›PMID 41705421›Full record

ArticleJournal of sleep research2026

The Natural History of Insomnia: Sleep Opportunity Extension Following a Poor Night of Sleep Is Not Related to the Transition From Acute to Chronic Insomnia.

Julia T Boyle, Knashawn H Morales, Ivan Vargas, Alexandria Muench, Donn A Posner, Michael A Grandner, Mark Seewald, Hannah Scott, Jason Ellis, Michael Perlis

Abstract read
In one paragraph

Article in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia T BoyleOffice of Research and Development, VA Boston Healthcare System, Boston, Massachusetts, USA.
Knashawn H MoralesDepartment of Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ivan VargasDepartment of Psychology, University of Notre Dame, Notre Dame, Indiana, USA.ORCID 0000-0002-0787-5630
Alexandria MuenchDepartment of Psychiatry, Penn Medicine Princeton Health, Plainsboro, New Jersey, USA.ORCID 0000-0003-4826-8498
Donn A PosnerSleepwell Consultants, Newtonville, Massachusetts, USA.
Michael A GrandnerDepartment of Psychiatry, University of Arizona, Tucson, Arizona, USA.
Mark SeewaldBehavioral Sleep Medicine Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hannah ScottCollege of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0002-0707-8068
Jason EllisNorthumbria Center for Sleep Research, Northumbria University, Newcastle, UK.
Michael PerlisBehavioral Sleep Medicine Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Prospective Assessment of The Etiology of Insomnia in Middle Aged & Elder AdultsR01AG041783 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PERLIS, MICHAEL LLOYD · 2013 to 2016
$2.4M
Behavioral Sleep Medicine: Training in Sleep and AgingK24AG055602 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Michael Lloyd Perlis · 2017 to 2026
$1.6M
Circadian and Ultradian Cortisol Rhythms in Chronic Sleep Continuity DisturbanceK23HL141581 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VARGAS, IVAN · 2019 to 2023
$677k
Economic and Social Research Council RES-061-25-0120-ANHLBI NIH HHS K23 HL141581NIA NIH HHS K24 AG055602NIA NIH HHS K24AG055602NIA NIH HHS R01 AG041783NIH HHS K23HL141581NIH HHS R01AG041783RRD VA IK1 RX004762VA Rehabilitation Research and Development IK1RX004762-01
6 · The paper itself

Abstract

The behavioural tendency to expand sleep opportunity to compensate for prior sleep loss is referred to as 'sleep extension.' It is believed that sleep extension (here referred to as 'sleep opportunity extension' [SOE]) is the primary perpetuating factor explaining the transition from acute to chronic insomnia. Recently, this proposition was prospectively evaluated by assessing how sleep opportunity varied, week-by-week, relative to the incidence of acute and chronic insomnia. Significant differences in sleep opportunity before and after onset of acute insomnia were not detected. In the present analysis, a more granular evaluation was undertaken to assess whether SOE occurs on the nights and/or weekends following poor sleep. The data set (n = 1243) was modelled by group (good sleepers and participants with acute insomnia) for SOE occurring on the nights and weekends following poor nights of sleep (i.e., ≥ 30 min of sleep latency and/or nocturnal wakefulness and/or early morning awakenings) for the post-acute insomnia interval. A linear mixed effects model was used to account for up to one year of night-to-night sleep per participant. During the weekdays, sleep opportunity following a poor night of sleep was not found to increase (overall or by group) (< 5 min). During the weekends, all groups tended to decrease their sleep opportunity. This counterintuitive finding casts further doubt on the proposition that SOE is responsible for the transition between acute insomnia and chronic insomnia. This finding does not, however, change the relevance of addressing the mismatch between sleep opportunity and ability as part of behavioural treatment.

Indexed as

SleepSleep Initiation and Maintenance DisordersAcute DiseaseAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedSleep DurationWakefulnessacute insomniaaginginsomnianatural historysleep extensionsleep opportunity extension

Identifiers

PMID41705421
PMCPMC13357965

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.