SynthesisHeadache2026
The association between posttraumatic stress disorder and migraine: A systematic review.
Synthesis in Headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this systematic review was to assess the magnitude of the association between posttraumatic stress disorder (PTSD) and migraine by synthesizing prevalence and incidence data from relevant studies.
backgroundMigraine is associated with reduced quality of life and an increased risk for psychiatric comorbidities. Recent evidence indicates a growing relevance of PTSD in this context.
methodsA comprehensive literature search was conducted in MEDLINE (via PubMed), EMBASE (via Elsevier), and PsycInfo (via EBSCOhost) from inception to November 22, 2024. Studies were eligible if they included adult populations and reported migraine prevalence or incidence in PTSD and non-PTSD groups. No restrictions were made regarding setting, language, or publication date. Two independent reviewers conducted study selection and data extraction. Results were narratively synthesized, and study quality was assessed using the Joanna Briggs Institute checklists.
resultsOf 12,801 records, 11 studies from five countries were included. Study populations included military personnel, general population, nurses, pregnant women, and students. Migraine prevalence (n = 9) was higher in individuals with PTSD (6.5%-46.5%) compared to those without (1.4%-25.8%), as were incidence estimates (n = 1; 48.5% vs. 39.5%) and incidence rates (n = 1; 5.74 vs. 1.22). All studies reported a positive association between PTSD and migraine, with ratios ranging from 1.2 to 4.7.
conclusionThis systematic review demonstrates a strong association between PTSD and migraine that extends beyond predisposed populations. These findings highlight the need for systematic trauma assessment in patients with chronic headache disorders. Future research should further explore this bidirectional interaction in population-based samples. PROSPERO study registration: CRD4202461764.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.