ArticleGenes & diseases2026
EEF1AKMT4-eEF1A2 synergistically facilitates the progression of GBC by promoting ribosomal protein output.
Article in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Mapping the global research landscape of tirzepatide: a bibliometric analysis of trends, collaborations, and emerging themes in obesity and diabetes managements.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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11 authors.
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Abstract
Gallbladder cancer (GBC) is prone to lymph node metastasis. Lymph node (LN) metastasis is correlated with abysmal patient prognosis, but the underlying mechanism remains elusive. In this study, transcriptome sequencing of 6 paired GBC tumors and metastatic LNs was performed and identified eEF1A2 as key genes associated with GBC LN metastasis. qPCR, Western blotting and immunohistochemistry (IHC) were performed to assess the expression of eEF1A2 and relating proteins in GBC. The function of eEF1A2 and its regulators were demonstrated in different GBC cell lines as well as in xenograft models. Two independent cohorts of GBC patients were used to reveal the clinical significance. The results revealed that eEF1A2 is tightly correlated with lymph node metastasis and poor prognosis in patients with GBC. In two GBC cell lines, eEF1A2 knockdown impaired cell proliferation, migration, and invasion
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