Evidence map›Paper›PMID 41705172›Full record

ArticleThe Lancet regional health. Southeast Asia2026

Comprehensive tuberculosis screening and preventive treatment in schools and congregate settings of India (2017-2024): a prospective study.

Kunchok Dorjee, Sonam Topgyal, Rajesh K Sood, Tenzin Namdon, Ravinder Kumar, Ugen Gyatso, Jigme Kalsang, Tenzin Thinley, Tenzin Dechen, Tenzin Tsomo and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Southeast Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Kunchok DorjeeDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Sonam TopgyalDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Rajesh K SoodNational TB Elimination Program, National Health Mission, Shimla, Himachal Pradesh, 171009, India.
Tenzin NamdonDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Ravinder KumarNational TB Elimination Program, National Health Mission, Shimla, Himachal Pradesh, 171009, India.
Ugen GyatsoDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Jigme KalsangDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Tenzin ThinleyDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Tenzin DechenDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Tenzin TsomoDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Tenzin KalsangDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Rachel C SadoffDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Sangyal DorjeeDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Sheriza BakshDepartment of Epidemiology, Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Tenzin YangkyiDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Tenzin KhachoeDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Tenzin DolkerDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Tsering WangmoDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Dekyi LhadonDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.
Lobsang TseringDepartment of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176219, India.
Amita GuptaDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Robert C BollingerDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jonathan E GolubDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Vidya MaveCentre for Infectious Diseases in India, Johns Hopkins India, Pune, Maharashtra, 411001, India.
Sourya ShresthaDepartment of International Health, Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Zorba PasterDepartment of Family Medicine, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Richard E ChaissonDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Tsetan D SadutshangDelek Hospital, Department of Health, Central Tibetan Administration, Dharamshala, Himachal Pradesh, 176215, India.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
NIAID NIH HHS P30 AI094189
6 · The paper itself

Abstract

Background: Existing Tuberculosis (TB) elimination strategies show limited impact, with suboptimal uptake of tuberculosis preventive treatment (TPT) and increasing TB incidence after the COVID-19 pandemic. Real-world evidence on reduction of tuberculosis in high-burden communities is needed to inform future TB elimination strategies. Methods: Since 2017, a comprehensive TB screening and TPT program known as Zero TB in Kids (ZTBK) was implemented in congregate settings of Tibetan communities in India. TB disease, TB infection (TBI), tuberculin skin test (TST) conversion, and TPT uptake were measured periodically. Findings: Schoolchildren and adults in 63 institutes (n = 20,068; 67,637 person-years) were screened. TPT was given to 3847 participants. TB incidence decreased 83% between 2017 [576 (95% CI: 455-718)/100,000] and 2024 [97 (47-179)/100,000]. TB infection (TBI) prevalence decreased 32% between 2017 [22% (95% CI: 21-23%)] and 2024 [15.5% (14-17%)]. TB incidence (640/100,000) and TBI prevalence (28%) were higher in the institutes that were never screened before under ZTBK. Among participants who did not receive TPT, TB disease prevalence decreased 84% between 2017 [910 (95% CI: 675-1204)/100,000] and 2024 [147 (48-343)/100,000], indicating a herd benefit. After one round of TB screening and TPT, between 2018 and 2019, TST conversion decreased 59% for children and 47% for adolescents. Risk of TBI was greater for males (aPR: 1.23; 95% CI: 1.16-1.30). TB risk was 82% lower for schoolchildren receiving TPT. Participants with seizure disorder [aPR: 0.31 (95% CI: 0.15-0.65)] and hepatitis B [0.71 (0.6-0.84)] were less likely to receive TPT. Interpretation: Significant reduction of TB transmission and burden can be achieved using the existing tools of TB control. Surveillance of TBI and TPT must be widely adopted for schools and congregate settings with high TB burden. Funding: National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIAID) (K01-AI148583), STOP TB Partnership (STBP/TBREACH/GSA/W7-7692), NIAID-Johns Hopkins Center for AIDS Research (90100777), Foundations, and Philanthropy.

Indexed as

Children or adolescentCongregate settingsPreventive treatmentTB eliminationTB transmissionTuberculosis

Identifiers

PMID41705172
PMCPMC12907724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.