ReviewResearch (Washington, D.C.)2026
Neuroregulatory Biomaterials for Intervertebral Disc Regeneration via Neuro-Disc Microenvironment Modulation.
Review in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- In Situ Stress-Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intervertebral discs have long been considered to lack neural innervation. However, recent studies have revealed that intervertebral disc degeneration is accompanied by marked pathological nerve invasion. In addition, the transmission mechanism of degeneration and related pain is exacerbated through the neural intervertebral disc microenvironment interaction network. Despite advances in this field, comprehensive reviews remain limited, and systematic analyses are lacking. In this review, we aimed to systematically analyze the potential application of "neural intervertebral disc microenvironment interaction" in the repair of intervertebral disc degeneration. First, in this article, we discussed the neural innervation and functional characteristics of healthy intervertebral discs, elaborated on the mechanism of abnormal nerve growth in the microenvironment of degenerated intervertebral discs, and explained how nerve invasion exacerbates intervertebral disc degeneration and its clinical symptoms by activating pain transmission pathways. Subsequently, we reviewed bioengineering strategies that provided new pathways for the innovative treatment of intervertebral disc degeneration through the synergistic effects of neural regulation and microenvironment interactions. Finally, we explored application prospects of neural-regulated biomaterials in precision medicine, clinical translation, and interdisciplinary fusion, providing a theoretical basis and technical guidance for neural-based intervertebral disc regeneration therapy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.